Section 48
Chapter 47,788

Ticlopidine and aspirin in the treatment of unstable angina: comparative evaluation of their effect of anti-aggregation and platelet membranes

Shalaev, S.V.; Mezhetskaia, I.A.

Kardiologiia 33(5): 9-12


ISSN/ISBN: 0022-9040
PMID: 7967338
Accession: 047787629

The study was undertaken to examine changes in ADP-induced aggregation of platelets, blood-circulating platelet aggregates, platelet phospholipids and cholesterol in patients with unstable angina depending on the therapy with disaggregatory agents. The patients from Group 1 (n = 23) received ticlopidine, 500 mg/day, in addition to antianginal therapy and heparin; those from Group 2 (n = 21) had aspirin, 320 mg/day, those from Group 3 (n = 36) took no disaggregahts. Ticlopidine was found to produce more marked effects on ADT-induced plasma platelet aggregation, in vivo reversible platelet aggregation, and reduced platelet levels of free cholesterol, as compared to aspirin.

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