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Use of toxic fraction isolated from Algerian Androctonus australis hector scorpion venom for the assessment of anti-venom serum


Use of toxic fraction isolated from Algerian Androctonus australis hector scorpion venom for the assessment of anti-venom serum



Archives de l'Institut Pasteur d'Algerie. Institut Pasteur d'Algerie 62: 254-266



ISSN/ISBN: 0020-2460

PMID: 11256315

Today, serotherapy is the only specific treatment used against the scorpionique envenomation. This treatment was associated with other drugs as a symptomatic and supportive care. The anti-venom against scorpion stings is still prepared using the conventional manufacturing production. To evaluate the efficacy of the anti-venom, different protocols are used: The immunization of animals (rabbit and horse) with a whole toxic fraction prepared by molecular filtration was the first step to improve the anti-venom. Some observations also show the need for the quality control of this preparation of anti-venom. In this study, we describe the use the toxic fraction isolated from Androctonus australis Hector in the new protocol of anti-venom production. The quality control of the product is evaluated by using a combination of experimental immunological assay systems (ELISA, Hemaglutination, in vivo assessment of the neutralization of the lethal effect of the venom).

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Accession: 047901525

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Toxic fraction isolated from Algerian scorpion Androctonus australis Hector and their use in anti-venom production Utilisation de la fraction toxique majoritaire isolee a partir du venin de scorpion Androctonus australis Hector dAlgerie dans la valorisation du serum anti-scorpionique. Archives de l'Institut Pasteur d'Algerie 62: 254-266, 1999

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