+ Site Statistics
References:
52,654,530
Abstracts:
29,560,856
PMIDs:
28,072,755
+ Search Articles
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ PDF Full Text
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn

+ Translate
+ Recently Requested

Uveal and capsular biocompatibility of 2 foldable acrylic intraocular lenses in patients with uveitis or pseudoexfoliation syndrome: comparison to a control group



Uveal and capsular biocompatibility of 2 foldable acrylic intraocular lenses in patients with uveitis or pseudoexfoliation syndrome: comparison to a control group



Journal of Cataract and Refractive Surgery 28(7): 1160-1172



To evaluate the uveal and capsular biocompatibility of hydrophilic acrylic (Hydroview) and hydrophobic acrylic (AcrySof) intraocular lenses (IOLs) after phacoemulsification in eyes with pseudoexfoliation syndrome (PEX) or uveitis and compare the results with those in a control group. Department of Ophthalmology, University of Vienna, Vienna, Austria. This prospective nonrandomized comparative trial comprised 143 eyes recruited consecutively. Of these, 49 eyes had PEX, 43 had uveitis, and 51 served as controls. A standardized surgical protocol was used. Cell reaction, anterior (ACO) and posterior (PCO) capsule opacification, and flare were evaluated 1 year after cataract surgery. Regarding uveal biocompatibility, the number of foreign-body giant cells (FBGCs) increased in proportion to associated ocular pathologies in both IOL groups. The difference between the Hydroview control and Hydroview uveitis groups was statistically significant. The number of FBGCs was greater on AcrySof IOLs than on Hydroview IOLs in all 3 groups. The difference in FBGCs between the 2 IOL types was statistically significant in the control and PEX groups. Regarding capsular biocompatibility, lens epithelial cell (LEC) outgrowth was inversely correlated with intraocular inflammation. Outgrowth was statistically significantly higher with Hydroview IOLs, occurring in 85% in the control group, 45% in the PEX group, and 28% in the uveitis group (P <.0001). With AcrySof lenses, the percentages were 0%, 8%, and 4%, respectively. The PEX and uveitis groups were more likely to develop ACO than the control group (P <.012). There was no statistically significant difference in ACO between the 2 IOL types in the 3 patient groups. The PCO was statistically significantly greater in the uveitis group than in the control group (P <.026) and statistically significantly more dense on Hydroview than on AcrySof IOLs in all 3 patient groups (P <.002). Flare was statistically significantly higher in the uveitis group than in the PEX and control groups with both IOL types (P <.012). There was no statistically significant difference in flare between the 2 IOL types. Uveal and capsular biocompatibility depends on the intensity of ocular inflammation. The greater the inflammation, the less the biocompatibility of hydrophilic and hydrophobic acrylic materials. AcrySof stimulated more FBGCs. The Hydroview material had better uveal but poorer capsular biocompatibility than AcrySof. The sharp optic edge effect of the AcrySof IOL and the advantages of the Hydroview lens in normal eyes are less apparent in compromised eyes.

(PDF emailed within 0-6 h: $19.90)

Accession: 047910105

Download citation: RISBibTeXText

PMID: 12106724

DOI: 10.1016/s0886-3350(02)01360-3



Related references

Uveal and capsular biocompatibility of two foldable acrylic intraocular lenses in patients with endogenous uveitis--a prospective randomized study. Graefe's Archive for Clinical and Experimental Ophthalmology 246(11): 1609-1615, 2008

Uveal and Capsular Biocompatibility After Implantation of Hydrophilic-acrylic, Hydrophobic-acrylic and Silicone Intraocular Lenses in Eyes with Pseudoexfoliation Syndrome. ARVO Annual Meeting Abstract Search & Program Planner : Abstract No 423, 2002

Uveal and capsular biocompatibility after implantation of sharp-edged hydrophilic acrylic, hydrophobic acrylic, and silicone intraocular lenses in eyes with pseudoexfoliation syndrome. Journal of Cataract and Refractive Surgery 33(8): 1414-1418, 2007

Uveal and capsular biocompatibility of hydrophilic acrylic, hydrophobic acrylic, and silicone intraocular lenses. Journal of Cataract and Refractive Surgery 28(1): 50-61, 2002

Inflammation after implantation of hydrophilic acrylic, hydrophobic acrylic, or silicone intraocular lenses in eyes with cataract and uveitis: comparison to a control group. Journal of Cataract and Refractive Surgery 28(7): 1153-1159, 2002

Comparison of PMMA, foldable silicone and foldable acrylic hydrophobic intraocular lenses in combined phacoemulsification and trabeculectomy. Arquivos Brasileiros de Oftalmologia 68(1): 29-35, 2005

Biocompatibility of hydrophilic acrylic, hydrophobic acrylic, and silicone intraocular lenses in eyes with uveitis having cataract surgery: Long-term follow-up. Journal of Cataract and Refractive Surgery 37(1): 104-112, 2011

Comparison of foldable intraocular lenses in uveitis. IOVS 40(4): S151, March 15, 1999

Postoperative inflammatory response to phacoemulsification and implantation of 2 types of foldable intraocular lenses in pseudoexfoliation syndrome. Klinische Monatsblatter für Augenheilkunde 217(1): 10-14, 2000

In vivo comparison of silicone and acrylic foldable intraocular lenses. Investigative Ophthalmology & Visual Science 38(4 PART 1-2): S546, 1997

Comparison of the biocompatibility of 2 foldable intraocular lenses with sharp optic edges. Journal of Cataract and Refractive Surgery 27(10): 1579-1585, 2001

Uveal and capsular biocompatibility of a single-piece, sharp-edged hydrophilic acrylic intraocular lens with collagen (Collamer): 1-year results. Journal of Cataract and Refractive Surgery 30(6): 1254-1258, 2004

Results of hydrophilic acrylic, hydrophobic acrylic, and silicone intraocular lenses in uveitic eyes with cataract: comparison to a control group. Journal of Cataract and Refractive Surgery 28(7): 1141-1152, 2002

Comparison of the Biocompatibility of 2 Foldable Hydrophilic One-piece Intraocular Lenses With Different Haptic Angulation. ARVO Annual Meeting Abstract Search & Program Planner : Abstract No 419, 2002

Posterior capsule opacification after extra capsular cataract extraction in Indian rural population foldable acrylic vs poly intraocular lenses a randomized clinical trial. Eye: 7, 889-894, 2008