+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

What is the best proton energy for accelerator-based BNCT using the 7Li(p,n)7Be reaction?



What is the best proton energy for accelerator-based BNCT using the 7Li(p,n)7Be reaction?



Medical Physics 27(5): 1113-1118



With a growing interest in the use of accelerator-based epithermal neutron sources for BNCT programs, in particular those based upon the 7Li(p,n)7Be reaction, there is a need to address the question of "what is the best proton energy to use?" This paper considers this question by using radiation transport calculations to investigate a range of proton energies from 2.15 to 3.5 MeV and a range of moderator sizes. This study has moved away completely from the use of empty therapy beam parameters and instead defines the beam quality and optimizes the moderator design using widely accepted in-phantom treatment planning figures of merit. It is concluded that up to a proton energy of about 2.8 MeV there is no observed variation in the achievable therapy beam quality, but a price is paid in terms of treatment time for not choosing the upper limit of this range. For higher proton energies, the beam quality falls, but with no improvement in treatment time for optimum configurations.

Please choose payment method:






(PDF emailed within 0-6 h: $19.90)

Accession: 047958685

Download citation: RISBibTeXText

PMID: 10841417

DOI: 10.1118/1.598976


Related references

Variations in lithium target thickness and proton energy stability for the near-threshold 7Li(p,n)7Be accelerator-based BNCT. Physics in Medicine and Biology 52(3): 645-658, 2007

An experimental study of the moderator assembly for a low-energy proton accelerator neutron irradiation facility for BNCT. Basic Life Sciences 54: 271-280, 1990

In-phantom dosimetry for the 13C(d,n)14N reaction as a source for accelerator-based BNCT. Medical Physics 28(5): 796-803, 2001

Design study on an accelerator-based facility for BNCT and low energy neutron source. Progress in Nuclear Energy 37(1-4): 321-326, 2000

Characteristics of proton beam scanning dependent on Li target thickness from the viewpoint of heat removal and material strength for accelerator-based BNCT. Applied Radiation and Isotopes 67(2): 259-265, 2009

Application of a Bonner sphere spectrometer for the determination of the angular neutron energy spectrum of an accelerator-based BNCT facility. Applied Radiation and Isotopes 88: 216-220, 2014

Computational assessment of deep-seated tumor treatment capability of the 9Be(d,n)10B reaction for accelerator-based boron neutron capture therapy (AB-BNCT). Physica Medica 30(2): 133-146, 2014

Optimized therapeutic neutron beam for accelerator-based BNCT by analyzing the neutron angular distribution from (7)Li(p,n)(7)Be reaction. Applied Radiation and Isotopes 67(7-8): 1173-1179, 2009

Accelerator-based BNCT. Applied Radiation and Isotopes 88: 185-189, 2014

Design of a new BNCT facility based on an ESQ accelerator. Larsson, B, Crawford, J, Weinreich, R International Congress Series; Advances in Neutron capture therapy, Vol 1 Medicine and physics 533-537, 1997

Present status of Accelerator-Based BNCT. Reports of Practical Oncology and RadioTherapy 21(2): 95, 2016

Overview of the IBA accelerator-based BNCT system. Applied Radiation and Isotopes 67(7-8 Suppl): S262-S265, 2009

Development of BNCT based on research using accelerator based neutron source. Igaku Butsuri 32(3): 104-110, 2012

An accelerator-based thermal neutron source for BNCT. Larsson, B, Crawford, J, Weinreich, R International Congress Series; Advances in Neutron capture therapy, Vol 1 Medicine and physics 483-489, 1997

A Pet System Based on 2- 18 Fdg Production with a Low Energy Electrostatic Proton Accelerator and a Dual Headed Pet Scanner. Acta Oncologica 31(7): 771-776, 1992