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A comparison of Plateletworks and platelet aggregometry for the assessment of aspirin-related platelet dysfunction in cardiac surgical patients



A comparison of Plateletworks and platelet aggregometry for the assessment of aspirin-related platelet dysfunction in cardiac surgical patients



Journal of Cardiothoracic and Vascular Anesthesia 18(2): 136-140



To compare the assessment of aspirin-related platelet dysfunction using Plateletworks (Helena Laboratories, Beaumont, TX), a new point-of-care platelet function analyzer, with turbidometric platelet aggregometry, in cardiac surgical patients. Prospective observational study. University-affiliated teaching hospital. Fifty consecutive adult patients undergoing elective cardiac surgery for coronary artery bypass grafting or cardiac valve replacement. None. Platelet function was assessed by Plateletworks and turbidometric platelet aggregometry before the commencement of anesthesia. Collagen, 10 microg/mL, was used as the agonist for both techniques. The area under the receiver-operator curve for the identification of recent aspirin ingestion (or=72 hours) using Plateletworks was 0.58 (95% confidence interval [CI] 0.42-0.75) versus 0.77 (95% CI 0.61-0.95) for turbidometric platelet aggregometry. The Spearman correlation coefficient (rho) between preoperative Plateletworks trade mark and postoperative mediastinal blood loss was 0.07 (p = 0.58), and between preoperative turbidometric platelet aggregometry and postoperative mediastinal blood loss was -0.31 (p = 0.03). On completion of surgery, the correlation coefficients were 0.14 (p = 0.34) and -0.29 (p = 0.08), respectively. These findings suggest that Plateletworks is of limited use for the detection of aspirin-related platelet defects in cardiac surgical patients.

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Accession: 048057135

Download citation: RISBibTeXText

PMID: 15073699

DOI: 10.1053/j.jvca.2004.01.015


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