A new protecting group for the 5'-hydroxyl group having O-S single bond oxidatively cleavable under mild conditions
Utagawa, E.; Seio, K.; Sekine, M.
Nucleosides Nucleotides and Nucleic Acids 24(5-7): 927-929
ISSN/ISBN: 1525-7770 PMID: 16248064 DOI: 10.1081/ncn-200059288
We developed a new protecting group, ie., cis-[4-[[(4-methoxytrityl)sulfenyl]oxy]tetrahydrofuran-3-yl]oxycarbonyl (MTFOC), which could be removed under neutral conditions involving the oxidative removal of the MMTrS group followed by the self-cyclization of the resulting intermediate. The introduction of the protecting group into the 5-hydroxyl group of a thymidine derivative and its deprotection were studied.