EurekaMag
+ Most Popular
Cunninghamia lanceolata plantations in China
Mammalian lairs in paleo ecological studies and palynology
Studies on technological possibilities in utilization of anhydrous milk fat for production of recombined butter-like products
Should right-sided fibroelastomas be operated upon?
Large esophageal lipoma
Apoptosis in the mammalian thymus during normal histogenesis and under various in vitro and in vivo experimental conditions
Poissons characoides nouveaux ou non signales de l'Ilha do Bananal, Bresil
Desensitizing efficacy of Colgate Sensitive Maximum Strength and Fresh Mint Sensodyne dentifrices
Administration of fluid by subcutaneous infusion: revival of a forgotten method
Tundra mosquito control - an impossible dream?
Schizophrenia for primary care providers: how to contribute to the care of a vulnerable patient population
Geochemical pattern analysis; method of describing the Southeastern limestone regional aquifer system
Incidence of low birth weights in a hospital of Mexico City
Tabanidae
Graded management intensity of grassland systems for enhancing floristic diversity
Microbiology and biochemistry of cheese and fermented milk
The ember tetra: a new pygmy characid tetra from the Rio das Mortes, Brazil, Hyphessobrycon amandae sp. n. (Pisces, Characoidei)
Risk factors of contrast-induced nephropathy in patients after coronary artery intervention
Renovation of onsite domestic wastewater in a poorly drained soil
Observations of the propagation velocity and formation mechanism of burst fractures caused by gunshot
Systolic blood pressure in a population of infants in the first year of life: the Brompton study
Haematological studies in rats fed with metanil yellow
Studies on pasteurellosis. I. A new species of Pasteurella encountered in chronic fowl cholera
Dormancy breaking and germination of Acacia salicina Lindl. seeds
therapy of lupus nephritis. a two-year prospective study

Advance in antitumor agents targeting glutathione-S-transferase


Advance in antitumor agents targeting glutathione-S-transferase



Current Medicinal Chemistry 13(12): 1461-1471



ISSN/ISBN: 0929-8673

PMID: 16719788

DOI: 10.2174/092986706776872934

Glutathione-S-transferases (GSTs; EC 2.5.1.18), a family of phase II detoxification enzymes, catalyze the conjugation of glutathione with broad substrates including chemotherapeutic agents, and are involved in cell protection against apoptotic signals by inhibiting the stress-signaling cascade mediated by ASK1 (Apoptosis signal-regulating kinase)-JNK (c-Jun N-terminal kinase). As GSTs are overexpressed in some malignant tumors, GSTs is a promising therapeutic target. This article reviews the progress in the development of GSTs inhibitors and GSTs activated prodrugs.

Accession: 048190116

Download citation: RISBibTeXText

Related references

Advance in Antitumor Agents Targeting Glutathione-S-Transferase. Current Medicinal Chemistry 13(12): 1461-1471, 2006

The role of p-glycoprotein, glutathione-s-transferase-pi, thymidylate synthase and metallothionein in the expression of differential sensitivities to antitumor agents in human tumor xenografts. Oncology Reports 1(5): 927-932, 1994

Antitumor agents. Part 227: Studies on novel 4$prime;-O-demethyl-epipodophyllotoxins as antitumor agents targeting topoisomerase Ii*1. Bioorganic and Medicinal Chemistry 12(12): 3339-3344, 2004

Antitumor agents. Part 227: Studies on novel 4'-O-demethyl-epipodophyllotoxins as antitumor agents targeting topoisomerase II. Bioorganic and Medicinal Chemistry 12(12): 3339-3344, 2004

PNU-166196, a novel antitumor agent with enhanced activity in tumors expressing high glutathione and/or glutathione-S-transferase levels. Proceedings of the American Association for Cancer Research Annual Meeting 42: 326, 2001

Estrogen receptor 1, glutathione S-transferase P1, glutathione S-transferase M1, and glutathione S-transferase T1 genes with dysmenorrhea in Korean female adolescents. Korean Journal of Laboratory Medicine 30(1): 76-83, 2010

Polymorphisms of glutathione S-transferase Mu 1, glutathione S-transferase theta 1 and glutathione S-transferase Pi 1 genes in Hodgkin's lymphoma susceptibility and progression. Leukemia and Lymphoma 50(6): 1005-1009, 2009

Evaluation of Genetic Polymorphisms in Glutathione S-Transferase Theta1, Glutathione S-Transferase Mu1, and Glutathione S-Transferase Mu3 in Oral Leukoplakia and Oral Squamous Cell Carcinoma with Deleterious Habits using Polymerase Chain Reaction. International Journal of Applied and Basic Medical Research 7(3): 181-185, 2017

Glutathione S-transferase (transferase pi) from human placenta is identical or closely related to glutathione S-transferase (transferase rho) from erythrocytes. Biochimica et Biophysica Acta 661(2): 255-260, 1981

Glutathione S-transferase (transferase ) from human placenta is identical or closely related to glutathione S-transferase (transferase ) from erythrocytes. Biochimica et Biophysica Acta - Enzymology 661(2): 255-260, 1981

Advance in glutathione S-transferase kappa 1. Zhong Nan da Xue Xue Bao. Yi Xue Ban 42(4): 468-475, 2017

Reaction kinetics and targeting to cellular glutathione S-transferase of the glutathione peroxidase mimetic PhSeZnCl and its D,L-polylactide microparticle formulation. Free Radical Biology and Medicine 78: 56-65, 2015

Cellular glutathione (GSH) and glutathione S-transferase (GST) activity in human ovarian tumor biopsies following exposure to alkylating agents. International Journal of Radiation Oncology Biology Physics 24(3): 527-531, 1992

Purification and physical characterization of glutathione S-transferase K. Differential use of S-hexylglutathione and glutathione affinity matrices to isolate a novel glutathione S-transferase from rat liver. Biochemical Journal 233(3): 789-798, 1986

Normal bronchial epithelial cell expression of glutathione transferase P1, glutathione transferase M3, and glutathione peroxidase is low in subjects with bronchogenic carcinoma. Cancer Research 60(6): 1609-1618, 2000