+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

An analysis of cervical lymph nodes metastasis in oral squamous cell carcinoma. Relationship between grade of histopathological malignancy and lymph nodes metastasis



An analysis of cervical lymph nodes metastasis in oral squamous cell carcinoma. Relationship between grade of histopathological malignancy and lymph nodes metastasis



International Journal of Oral and Maxillofacial Surgery 32(3): 284-288



Cervical lymph nodes metastasis is well known to be an indicator of poor prognosis in patients with oral cancer. This study was considered 38 patients of oral squamous cell carcinoma who were treated at our department from 1993 to 1997. Histological malignancy of initial biopsy in the pretreatment period was evaluated by Anneroth's classification. The relationship of degree of histological malignancy with cervical lymph nodes metastasis were analysed in this study. Metastasis in the cervical lymph nodes was histologically confirmed in 17 out of 38 cases (44.7%). The metastasis located predominantly in the submandibular nodes and superior internal jugular nodes. According to T classification, the rate of metastasis in the cervical lymph nodes in T1 and T2 cases was around 30%, while the rate in T3 and T4 cases tended to be as high as around 60%. However, there was no significant difference. A significant relation was evident between the degree of histological malignancy and metastasis in the cervical lymph nodes (P< 0.01), indicating that the histological malignancy could be served as a predictor for metastasis in the cervical lymph nodes. Among the six parameters, a significant difference was observed only in the degree of keratinization and the mode of invasion (P< 0.05). When the sum of the degree of histological malignancy exceeds 15, metastasis in the cervical lymph nodes should be considered.

Please choose payment method:






(PDF emailed within 0-6 h: $19.90)

Accession: 048226089

Download citation: RISBibTeXText

PMID: 12767876

DOI: 10.1054/ijom.2002.0303


Related references

Ultrasound diagnosis of cervical lymph node metastasis and histopathological characteristics of false negative lymph nodes in patients with oral squamous cell carcinoma. Sapporo Medical Journal 72(1-2): 15-21, 2003

Cervical lymph node metastasis in oral squamous cell carcinoma: a correlative study between histopathological malignancy grading and lymph node metastasis. Indian Journal of Dental Research 24(5): 599-604, 2015

Risk Factors Analysis of Pathologically Confirmed Cervical Lymph Nodes Metastasis in Oral Squamous Cell Carcinoma Patients with Clinically Negative Cervical Lymph Node: Results from a Cancer Center of Central China. Journal of Cancer 10(13): 3062-3069, 2019

Cervical Lymph Node Metastasis and Histopathological Malignancy Grading of Primary Oral Squamous Cell Carcinoma. Asian Journal of Oral and Maxillofacial Surgery 21(3-4): 81-87, 2009

Immunologic reaction of cervical lymph nodes in relation to metastasis and prognosis of oral squamous cell carcinoma. Zhonghua Kou Qiang Ke Za Zhi 15(1): 5-7, 1980

Relationship among expression of the VEGF gene and MVD with cervical lymph nodes metastasis in laryngeal squamous cell carcinoma. Lin Chuang Er Bi Yan Hou Ke Za Zhi 18(2): 100-102, 2004

Analysis of CD8+ and CD4+ cells in oral squamous cell carcinoma and their association with lymph node metastasis and histologic grade of malignancy. Applied Immunohistochemistry and Molecular Morphology 22(3): 200-205, 2014

Expression of thymidylate synthase and dihydropyrimidine dehydrogenase in primary oral squamous cell carcinoma and corresponding metastases in cervical lymph nodes: association with the metastasis suppressor CD82. Anticancer Research 31(10): 3521-3526, 2011

Preoperative evaluation of cervical lymph nodes for metastasis in patients with oral squamous cell carcinoma: A comparative study of efficacy of palpation, ultrasonography and computed tomography. National Journal of Maxillofacial Surgery 7(2): 186-190, 2017

The Number of Positive Pelvic Lymph Nodes and Multiple Groups of Pelvic Lymph Node Metastasis Influence Prognosis in Stage IA-IIB Cervical Squamous Cell Carcinoma. Chinese Medical Journal 128(15): 2084-2089, 2015

Oral cavity and oropharynx squamous cell carcinoma with metastasis to the parotid lymph nodes. Oral Oncology 47(2): 142-144, 2011

Studies on Metastasis of Cancer 18. Experiments on Lymph Nodes Metastasis with Reference to Preventive Effect of Surgical Removal of the Regional Lymph Nodes on Recurrence and Metastasis. Science Reports of the Research Institutes Tohoku University. Ser. C Medicine. Tohoku Daigaku 11: 406-418, 1964

The effects of MMPs and TIMPs on the metastasis of oral squamous cell carcinoma to neck lymph nodes. Hua Xi Kou Qiang Yi Xue Za Zhi 19(4): 216-8 224, 2001

Covering of parotid and cervical lymph nodes metastasis of cutaneous squamous cell carcinoma of the head, about 18 cases. Revue de Laryngologie - Otologie - Rhinologie 136(1): 9-15, 2016

Assessment of Density of Neovascularization in Lower Lip Squamous Cell Carcinoma in Relation To Neoplasm Differentiation Grade in Patients with and without Neck Lymph Nodes Metastasis. Open Access Macedonian Journal of Medical Sciences 7(1): 19-23, 2019