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Antimicrobial susceptibility testing of clinical isolates of Haemophilus influenzae derived from Japanese children



Antimicrobial susceptibility testing of clinical isolates of Haemophilus influenzae derived from Japanese children



Kansenshogaku Zasshi. Journal of the Japanese Association for Infectious Diseases 78(11): 943-951



We examined the antimicrobial susceptibility testing of 1,024 Haemophilus influenzae isolates recovered from Japanese children. Percent distribution of beta-lactamase-negative ampicillin (ABPC)--resistant strain (BLNAR; ABPC-MIC > or = 4 microg/ml) was 15.0%. Prevalence of BLNAR increased remarkably from 12.7 to 22.1% in recent 4 years. Furthermore, the frequency of highly resistant strains (ABPC-MIC > or = 8 microg/ml) increased from 28.6 to 56.9% among BLNAR. Decreased susceptibility for cephems was observed in non-BLNAR strains including serotype b strain isolated from the cerebrospinal fluid.

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Accession: 048282064

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PMID: 15628526


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