+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Antiviral strategies against human coronaviruses



Antiviral strategies against human coronaviruses



Infectious Disorders Drug Targets 7(1): 59-66



Since the mid 60's the human coronaviruses (HCoV), represented by HCoV-OC43 and HCoV-229E, were generally considered relatively harmless viruses. This status changed dramatically with the emergence of SARS-CoV in 2002/2003. The SARS-CoV pandemic took 774 lives around the globe and infected more than 8000 people in 29 countries. SARS-CoV is believed to be of zoonotic origin, transmitted from its natural reservoir in bats through several animal species (e.g., civet cats, raccoon dogs sold for human consumption in markets in southern China). The epidemic was halted in 2003 by a highly effective global public health response, and SARS-CoV is currently not circulating in humans. The outbreak of SARS-CoV and the danger of its re-introduction into the human population, as well as the danger of the emergence of other zoonotic coronaviral infections triggered an intense survey for an efficient treatment that resulted in the evaluation of several anticoronaviral compounds. HCoV-NL63 and HCoV-HKU1 were identified shortly after the SARS-CoV outbreak. The 4 human coronaviruses HCoV-229E, HCoV-OC43, HCoV-NL63 and HCoV-HKU1 cause mild respiratory illnesses when compared to SARS, but these infections are involved in 10 - 20 % of hospitalizations of young children and immunocompromised adults with respiratory tract illness. Therefore, there is an urgent need for a successful therapy to prevent disease induction or a vaccine to prevent new infections. This review summarizes the current status of anticoronaviral strategies.

Please choose payment method:






(PDF emailed within 1 workday: $29.90)

Accession: 048285508

Download citation: RISBibTeXText

PMID: 17346212


Related references

Antiviral Strategies Against Human Coronaviruses. Infectious Disorders - Drug Targets 7(1): 59-66, 2007

A molecular arms race between host innate antiviral response and emerging human coronaviruses. Virologica Sinica 31(1): 12-23, 2016

Human coronaviruses: insights into environmental resistance and its influence on the development of new antiseptic strategies. Viruses 4(11): 3044-3068, 2012

Surveillance of Bat Coronaviruses in Kenya Identifies Relatives of Human Coronaviruses NL63 and 229E and Their Recombination History. Journal of Virology 91(5):, 2017

Antigenic relationships among the coronaviruses of man and between human and animal coronaviruses. Journal of Immunology 102(5): 1109-1118, 1969

Coronaviruses SD and SK share extensive nucleotide homology with murine coronavirus MHV-A59, more than that shared between human and murine coronaviruses. Virology 126(2): 669-677, 1983

Antiviral drugs specific for coronaviruses in preclinical development. Current Opinion in Virology 8: 45-53, 2014

Interaction of SARS and MERS Coronaviruses with the Antiviral Interferon Response. Advances in Virus Research 96: 219-243, 2016

Broad-spectrum antiviral GS-5734 inhibits both epidemic and zoonotic coronaviruses. Science Translational Medicine 9(396):, 2017

Immune evasion of porcine enteric coronaviruses and viral modulation of antiviral innate signaling. Virus Research 226: 128-141, 2016

Cell-based antiviral screening against coronaviruses: developing virus-specific and broad-spectrum inhibitors. Antiviral Research 101: 105-112, 2014

Avoiding Regions Symptomatic of Conformational and Functional Flexibility to Identify Antiviral Targets in Current and Future Coronaviruses. Genome Biology and Evolution 8(11): 3471-3484, 2016

Antiviral strategies in the replication of human immunodeficiency virus. L'Union Medicale du Canada 121(5): 307-9 312-4, 1992

Novel Antiviral Strategies to Combat Human Arenavirus Infections. Current Molecular Medicine 5(8): 735-751, 2005

Novel antiviral strategies to combat human Arenavirus infections. Current Molecular Medicine 5(8): 735-751, 2005