Section 49
Chapter 48,373

Antigen Presentation: Visualizing the MHC Class I Peptide-Loading Bottleneck

Lamers, M.; Berlin, I.; Neefjes, J.

Current Biology: Cb 28(2): R83-R86


ISSN/ISBN: 0960-9822
PMID: 29374452
DOI: 10.1016/j.cub.2017.11.059
Accession: 048372193

The peptide-loading complex is a bottleneck in antigen presentation by major histocompatibility complex (MHC) class I molecules. While the structures of its individual components were known, the recent report of the 7.2 Å structure of the entire complex now fits them into their functional context, explaining this monumental step in antigen acquisition by MHC class I molecules.

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