+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Characterization and incidence of inducible monomorphic ventricular tachycardia in a postinfarction rabbit model

Characterization and incidence of inducible monomorphic ventricular tachycardia in a postinfarction rabbit model

Journal of Electrocardiology 40(1): 89-93

Ventricular tachycardia (VT), occurring late after myocardial infarction, is an important cause of sudden death. Animal models are useful for the investigation of this arrhythmia. The aim of this study is to develop and characterize a model of late postinfarction monomorphic VT in the rabbit. Myocardial infarction was created by ligation of the left circumflex artery. Cardiac electrophysiologic studies were performed 10 to 17 days postinfarction in 39 rabbits, in 10 sham-operated rabbits, and 6 control rabbits. Ventricular tachycardia was defined as a broad-complex tachycardia with a cycle length of more than 100 milliseconds, a duration of more than 10 seconds, and monomorphic QRS complexes. Using programmed stimulation, we induced VT in 9 rabbits (23%) in the infarct group but in none of the sham or control animals. The mean infarct size was 23% +/- 9% (mean +/- SD) of the left ventricle. Coronary ligation in the rabbit creates a substrate, which allows the induction of sustained monomorphic VT with programmed stimulation. Monomorphic VT is not inducible in rabbits without myocardial infarction. This model might allow the testing of interventions that reduce the incidence of VT late after myocardial infarction.

Please choose payment method:

(PDF emailed within 0-6 h: $19.90)

Accession: 048495941

Download citation: RISBibTeXText

PMID: 17027019

DOI: 10.1016/j.jelectrocard.2006.02.001

Related references

Signal averaged electrocardiogram and inducible sustained monomorphic ventricular tachycardia in myocardial infarction patients without clinical ventricular tachycardia. Circulation 84(4 Suppl.): II648, 1991

The pathologic basis for inducible monomorphic ventricular tachycardia in the setting of chronic myocardial infarction in a porcine model. Modern Pathology 9(1): 28A, 1996

Is inducible sustained monomorphic ventricular tachycardia a reliable endpoint for treatment decisions in patients with asymptomatic nonsustained ventricular tachycardia and ejection fraction less than or equal to 40 percent?. Journal of the American College of Cardiology 29(2 Suppl. A): 515A, 1997

Postinfarction sudden death: significance of inducible ventricular tachycardia and infarct size in a conscious canine model. American Heart Journal 109(1): 8-18, 1985

Characterization of monomorphic and polymorphic ventricular tachycardia in a canine model of proarrhythmia. Circulation 90(4 Part 2): I248, 1994

Successful catheter ablation of unmappable monomorphic postinfarction ventricular tachycardia guided by a Purkinje potential. Pacing and Clinical Electrophysiology 35(5): E124-E126, 2012

Electrophysiological mechanisms of spontaneous termination of sustained monomorphic reentrant ventricular tachycardia in the canine postinfarction heart. Circulation 93(8): 1567-1578, 1996

Are there subgroups of patients at high risk for sudden death and cardiac arrest without inducible sustained monomorphic ventricular tachycardia Results from multicenter unsustained tachycardia trial. Circulation 100(18 Suppl. ): I 81, 1999

Inducible monomorphic sustained ventricular tachycardia in the conscious pig. American Heart Journal 119(5): 1042-1049, 1990

Effects of left ventricular reconstruction associated with non guided endocardectomy on inducible sustained ventricular tachycardia in postinfarction lv aneurysm. Journal of the American College of Cardiology 19(3 Suppl. A): 353A, 1992

Surgical ventricular restoration in patients with postinfarction coronary artery disease: effectiveness on spontaneous and inducible ventricular tachycardia. Seminars in Thoracic and Cardiovascular Surgery 13(4): 480-485, 2001

Prevalence, therapeutic response, and outcome of ventricular tachycardia in the out-of-hospital setting: a comparison of monomorphic ventricular tachycardia, polymorphic ventricular tachycardia, and torsades de pointes. Academic Emergency Medicine 6(6): 609-617, 1999

Limited effectiveness of magnesium infusions for suppressing inducible sustained monomorphic ventricular tachycardia. Circulation 80(4 Suppl. 2): II659, 1989

Clinical outcomes in elderly patients treated for inducible monomorphic sustained ventricular tachycardia. Journal of the American College of Cardiology 0(SPEC ISSUE): 100A, 1994

Sustained monomorphic ventricular tachycardia in the two-dimensional left ventricular epicardial sheets of rabbit hearts perfused in-vitro. Environmental Medicine 45(2): 92-94, 2001