+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Chronic morphine drinking establishes morphine tolerance, but not addiction in Wistar rats



Chronic morphine drinking establishes morphine tolerance, but not addiction in Wistar rats



Journal of Zhejiang University. Science. B 7(11): 892-898



Some animal models apply morphine in the drinking water to generate addiction, but related reports are not free of conflicting results. Accordingly, this study aimed to figure out if chronic consumption of morphine in the drinking water can induce morphine addiction in Wistar rats. For 3 weeks, the animals received a daily morphine dose of 35 mg/kg by offering a calculated volume of sugar water (5% sucrose) with morphine (0.1 mg/ml) to each rat; animals receiving just sugar water served as controls. Immediately after the treatment phase, the tail immersion test was used to check for morphine tolerance, and all animals were then kept on tap water for one week (withdrawal phase). Afterwards, all rats were allowed to choose their drinking source by offering two bottles, containing sugar water without and with morphine, simultaneously for two days (preference phase). While the chronic consumption of morphine led to a reduction in body weight and to morphine tolerance, the morphine-treated Wistar rats did not show any preference for the opiate-containing sugar water. Body weight loss and tolerance do not reveal a condition of drug craving, and current animal models should be re-evaluated regarding their potential to establish morphine addicted animals.

Please choose payment method:






(PDF emailed within 0-6 h: $19.90)

Accession: 048521189

Download citation: RISBibTeXText

PMID: 17048304

DOI: 10.1631/jzus.2006.b0892


Related references

Enkephalinase mechanisms of resistance and tolerance to the analgesic action of morphine in rats. I. Differential effects of D-phenylalanine in morphine-sensitive, morphine-tolerant, and morphine-resistant rats. Bulletin of Experimental Biology and Medicine 116(1): 828-831, 1993

Enkephalinase mechanisms of resistance and tolerance to the analgesic action of morphine in rats. II. Differential effects of naloxone in morphine-sensitive, morphine-resistant, and morphine-tolerant rats. Bulletin of Experimental Biology and Medicine 116(1): 762-766, 1993

The enkephalinase mechanisms of the resistance and tolerance to the analgesic effect of morphine in rats. Differences in the effects of naloxone in morphine-sensitive, morphine-resistant and morphine-tolerant rats. Biulleten' Eksperimental'noi Biologii i Meditsiny 116(7): 6-9, 1993

The enkephalinase mechanisms of the resistance and tolerance to the analgesic effect of morphine in rats. Differences in the effects of the action of D-phenylalanine in morphine-sensitive, morphine-tolerant and morphine-resistant rats. Biulleten' Eksperimental'noi Biologii i Meditsiny 116(7): 54-56, 1993

Development of tolerance following chronic apo morphine in rats and its effect on morphine hypo thermia. Federation Proceedings 33(3 Part 1): 502, 1974

The temperature response in rats during acute and chronic morphine administration, a study of morphine tolerance. Archives Internationales de Pharmacodynamie et de Therapie 129: 416-428, 1960

Adolescent chronic escalating morphine administration induces long lasting changes in tolerance and dependence to morphine in rats. Physiology and Behavior 174: 191-196, 2017

Effects of prenatally-administered morphine on brain development and resultant tolerance to the analgesic effect of morphine in offspring of morphine treated rats. Acta Pharmacologica et Toxicologica 36(3): 243-256, 1975

Antidiuretic effect of beta-endorphin and morphine in Brattleboro rats: development of tolerance and physical dependence after chronic morphine treatment. British Journal of Pharmacology 71(1): 51-56, 1980

Chronic morphine exposure and oxytocin neurons in rats lack of both morphine dependence and cross tolerance to endogenous opioids in the neurohypophysis. Journal of Physiology (Cambridge) 361: 32P, 1985

Reversal of morphine tolerance and dependence by Passiflora incarnata: A traditional medicine to combat morphine addiction. Pharmaceutical Biology 40(8): 576-580, 2002

Development and maintenance of morphine tolerance and dependence in the rat by scheduled access to morphine drinking solutions. Journal of Pharmacology and Experimental Therapeutics 205(3): 536-546, 1978

Place aversion by morphine in offspring born of female morphine administered wistar rats. Iranian Journal of Pharmaceutical Research 10(3): 577-584, 2011

Influence of phenobarbital on morphine metabolism and disposition: LC-MS/MS determination of morphine (M) and morphine-3-glucuronide (M3G) in Wistar-Kyoto rat serum, bile, and urine. Current Drug Metabolism 8(1): 79-89, 2007

Influence of actinomycin D on the emotional/behavioral effects of morphine and formation of morphine addiction in adult and old rats. Neurophysiology 31(4): 287-289, 1999