+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Clinical study of juvenile-onset recurrent respiratory papillomatosis



Clinical study of juvenile-onset recurrent respiratory papillomatosis



Zhonghua Er Bi Yan Hou Ke Za Zhi 36(6): 458-462



To study the clinical behavior of juvenile-onset recurrent respiratory papillomatosis in order to find some factors correlated to the development of this disease, and to sum up the significance and experience of CO2 laser surgery. Sixty patients with juvenile-onset recurrent respiratory papillomatosis from September 1995 to December 1998 were retrospectively analyzed. The age of onset in 50 cases (83.3%) was below 4 years, and the peak-age was 2 years. The rates of recurrence were 72.0% and 45.7% (chi 2 = 4.71, P < 0.05) below and over 2 years, respectively. The rates of aggressive disease were 88.0% and 54.3% (chi 2 = 7.66, P < 0.01) below and over 2 years, respectively. The predominant sites of the disease were the vocal cords, the false vocal cords, the laryngeal ventricle, the laryngeal surface of the epiglottis and the subglottic region. Tracheostomy induced the development of tracheal papilloma, therefore should be avoided as possible. Laryngeal papilloma might be divided into four types on the basis of the growth manner and surface form corresponding to clinical behaviors. Five patients were followed-up for 1.5 years without recurrence, 18 patients had fewer recurrences following treatment, 33 patients were under treatment, and 3 patients died. Nineteen patients lost follow-up. The major complications included laryngeal and tracheal stenosis. Clinical behaviors of juvenile-onset recurrent respiratory papillomatosis were relevant to the age, growth form and tracheotomy. CO2 laser was an ideal instrument for ablation of the laryngeal papillomas with the following advantages: simple management, less bleeding, preservation of laryngeal structure and avoidance of tracheostomy.

Please choose payment method:






(PDF emailed within 1 workday: $29.90)

Accession: 048557273

Download citation: RISBibTeXText

PMID: 12761965


Related references

HPV type determination and clinical characteristics in juvenile onset recurrent respiratory papillomatosis. Lin Chuang Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 30(9): 730-732;736, 2016

Clinical study of tracheotomies children with juvenile onset recurrent respiratory papillomatosis. Lin Chuang Er Bi Yan Hou Ke Za Zhi 20(15): 704-706, 2006

Current advances in the basic research and clinical management of juvenile-onset recurrent respiratory papillomatosis. European Archives of Oto-Rhino-Laryngology 257(5): 263-269, 2000

Human papillomavirus and host variables as predictors of clinical course in patients with juvenile-onset recurrent respiratory papillomatosis. Journal of Clinical Microbiology 35(12): 3098-3103, 1997

Clinical Activity of Nivolumab for Human Papilloma Virus-Related Juvenile-Onset Recurrent Respiratory Papillomatosis. Oncologist 24(6): 829-835, 2019

Clinical features, health-related quality of life, and adult voice in juvenile-onset recurrent respiratory papillomatosis. Laryngoscope 121(4): 846-851, 2011

Two cases of juvenile-onset and adult-onset recurrent respiratory papillomatosis. Nihon Kokyuki Gakkai Zasshi 49(9): 667-673, 2011

A comparison of risk factors in juvenile-onset and adult-onset recurrent respiratory papillomatosis. Laryngoscope 102(1): 9, 1992

Juvenile-onset recurrent respiratory papillomatosis. Advances in Oto-Rhino-Laryngology 73: 105-108, 2012

Juvenile-Onset Recurrent Respiratory Papillomatosis. Pediatric Asthma Allergy & Immunology 15(1): 59-62, 2001

Recurrent Respiratory Papillomatosis (RRP)-Juvenile Onset. Clinical Medicine. Oncology 2: 481-486, 2008

Risk factors of juvenile onset recurrent respiratory papillomatosis in the lower respiratory tract. Chinese Medical Journal 125(19): 3496-3499, 2012

The cost of juvenile-onset recurrent respiratory papillomatosis. Archives of Otolaryngology--Head and Neck Surgery 126(8): 935-939, 2000

Predictors of remission in juvenile-onset recurrent respiratory papillomatosis. Archives of Otolaryngology--Head and Neck Surgery 129(12): 1275-1278, 2003

Survivin expression in juvenile-onset recurrent respiratory papillomatosis. Annals of Otology Rhinology and Laryngology 111(11): 957-961, 2002