+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Cocirculation of measles virus genotype B2 and B3.1 in Central African Republic during the 2000 measles epidemic

Cocirculation of measles virus genotype B2 and B3.1 in Central African Republic during the 2000 measles epidemic

Journal of Medical Virology 78(7): 964-970

Many African countries have begun implementation of national programs to eliminate measles by the year 2015. However, measles continues to be endemic in Africa. This study describes the first molecular epidemiological study of measles virus circulating in Central African Republic. Two hundred and ten blood samples were tested for measles IgM. Sixty-seven urine samples were collected during measles outbreak in Bangui in 2000 and 2004 and used for genotyping studies. Two different methods were used to determine measles virus genotypes; the recently described real-time PCR-based method and the nucleotide sequencing and phylogenetic analysis methods. These tests revealed the cocirculation of two distinct viruses in Bangui. The proposed subgroup of the B3 genotype, B3.1 was found in 14 samples. This virus has been found in other neighboring countries. More surprising, genotype B2 was found in samples from four patients. The first measles genotype B2 viruses were isolated in Gabon in 1984, but have not been detected until recently when they were identified during a measles outbreak in 2003 in South Africa. This suggests that the circulation of measles genotype B2 has continued in Central Africa during the last 20 years. This study provides the baseline for genetic surveillance of measles virus in Central African Republic. Knowledge of currently circulating measles virus genotype in Central African Republic will help in monitoring the success of measles elimination program.

Please choose payment method:

(PDF emailed within 0-6 h: $19.90)

Accession: 048569470

Download citation: RISBibTeXText

PMID: 16721862

DOI: 10.1002/jmv.20648

Related references

Analysis of a subacute sclerosing panencephalitis (SSPE) Genotype B3 virus from the 2009/10 South African measles epidemic shows hyperfusogenic F proteins contribute to measles virus infection in the brain. Journal of Virology 2018, 2018

Analysis on the genotype of measles virus epidemic strains in Dongguan city, Guangdong province in 2000. Zhonghua Liu Xing Bing Xue Za Zhi 22(5): 355-358, 2001

Performance and reliability of the Enzygnost measles enzyme-linked immuno-sorbent assay for detection of measles virus-specific immunoglobulin M antibody during a large measles epidemic. Journal of Clinical Microbiology 30(3): 564-569, 1992

Molecular characterisation of measles virus strains among refugees from Central African Republic in Cameroon in 2014. Epidemiology and Infection 146(3): 319-323, 2018

Cocirculation of genotypes D4 and D6 in Greece during the 2005 to 2006 measles epidemic. Diagnostic Microbiology and Infectious Disease 62(1): 58-66, 2008

Risk factors for measles mortality and the importance of decentralized case management during an unusually large measles epidemic in eastern Democratic Republic of Congo in 2013. Plos one 13(3): E0194276, 2018

Canine distemper immunization. Persistence of measles antibodies in dogs vaccinated with measles virus and the effect of passively-transferred measles antibodies on vaccination of puppies with measles virus. Veterinary Medicine, Small Animal Clinician 62(11): 1065-1069, 1967

An epidemic of measles in southern Greenland, 1951 Measles in virgin soil HI Measles and tuberculosis. Acta Med Scand: 450-454, 1953

Measles incidence rate and a phylogenetic study of contemporary genotype H1 measles strains in China: is an improved measles vaccine needed?. Virus Genes 43(3): 319-326, 2011

New genotype of measles virus and update on global distribution of measles genotypes. Releve Epidemiologique Hebdomadaire 80(40): 347-351, 2005

Molecular epidemiology of measles virus in Iran 29–21 First detection of measles genotype H. 2011

Molecular epidemiology of measles virus in Iran 2009-2010: first detection of measles genotype H1. Journal of Medical Virology 83(12): 2200-2207, 2012

Measles re-emergence in Northern Italy: Pathways of measles virus genotype D8, 2013-2014. Infection, Genetics and Evolution 48: 120-126, 2016

Investigation of optimal specimen type and sampling time for detection of measles virus RNA during a measles epidemic. Journal of Clinical Microbiology 39(1): 375-376, 2001

The first measles outbreak caused by imported genotype D9 measles virus in Shandong Province, China, 2013. Japanese Journal of Infectious Diseases 67(4): 300-303, 2014