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Chapter 48,643

Construction of molecular logic gates with a DNA-cleaving deoxyribozyme

Chen, X.; Wang, Y.; Liu, Q.; Zhang, Z.; Fan, C.; He, L.

Angewandte Chemie 45(11): 1759-1762

2006

ISSN/ISBN: 1433-7851
PMID: 16470893
DOI: 10.1002/anie.200502511
Accession: 048642296
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A logical conclusion: Dna logic gates constructed by using a Cu2+-dependent DNA-cleaving deoxyribozyme are as efficient as the relatively unstable ribonucleotide-containing systems. The inputs (effectors), gates (deoxyribozymes), and outputs (substrates) are represented by chemically robust Dna oligonucleotides, which perform logic operations including "YES", "NOT", and "And (A,Not (B),Not (C))" (see picture).

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