EurekaMag.com logo
+ Site Statistics
References:
53,869,633
Abstracts:
29,686,251
+ Search Articles
+ Subscribe to Site Feeds
EurekaMag Most Shared ContentMost Shared
EurekaMag PDF Full Text ContentPDF Full Text
+ PDF Full Text
Request PDF Full TextRequest PDF Full Text
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter
Follow on LinkedInFollow on LinkedIn

+ Translate

Controversies with aspartame



Controversies with aspartame



Medicinski Pregled 56(Suppl. 1): 27-29



Artificial sweeteners are nowadays inevitable food additives, since they provide necessary food diversity to people suffering from diabetes. Aspartame is the most frequently used artificial sweetener ever and its safety profile is much better than that of saccharin or cyclamate. It received marketing approval in 1973, but only 3 months later aspartame was withdrawn because of allegations based on improperly designed experimental studies dealing with its carcinogen effects on rodent brain. However, extensive studies using the same model did not confirm such suspicions, and aspartame received a second marketing approval. Almost two decades later an epidemiological study found a relationship between aspartame and an increased frequency of brain tumors in humans. However, this study included a short time span of observation, and it did not estimate actual intake of aspartame, which led to loss of validity. Later on no epidemiological studies found correlation between aspartame use and incidence of brain tumors in humans. Up to now the only safety concern about aspartame, which received valid scientific proofs, is pro-seizure action of its excessive intake. In patients with epilepsy, excessive intake of aspartame can decrease the threshold for seizures or prolong them once they appear. However, if the intake is not above the recommended level of 40 mg/kg b.w./day, aspartame is well tolerated even in this subpopulation. Based on detailed analysis of published studies on safety of aspartame, it should not be restricted, but used in recommended amounts.

(PDF emailed within 1 workday: $29.90)

Accession: 048660932

Download citation: RISBibTeXText

PMID: 15510910



Related references

Studies on the stability of aspartame 1 specific and reproducible hplc assay for aspartame and its potential degradation products and applications to acid hydrolysis of aspartame. Die Pharmazie 46(3): 188-192, 1991

Development of an HPLC Method with an ODS Column to Determine Low Levels of Aspartame Diastereomers in Aspartame. Plos One 11(3): E0152174-E0152174, 2016

Aspartame sweetened soft drinks volume not aspartame is responsible for appetite suppression. FASEB Journal 5(5): A1314, 1991

Aspartame and aspartame derivatives effect human thrombin catalytic activity. Biophysical Chemistry 112(2-3): 285-291, 2004

Mixed crystals comprising aspartame and aspartame derivative and process for producing the same. Official Gazette of the United States Patent & Trademark Office Patents 1255(2), Feb 12, 2002

Studies on amino acids and peptides 7. syntheses of aspartame and thio aspartame. Tetrahedron 39(24): 4121-4126, 1983

Influence of storage conditions on quality soft drinks contain aspartame and aspartame/acesulfame K mixture. Prace Instytutow I Laboratoriow Badawczych Przemysu Spozywczego: , 63-76, 2008

Postingestive inhibition of food intake by aspartame: importance of interval between aspartame administration and subsequent eating. Physiology & Behavior 57(3): 489-493, 1995

Neurological psychiatric and behavioral reactions to aspartame in 505 aspartame reactors. Wurtman, R J And E Ritter-Walker (Ed ) Dietary Phenylalanine And Brain Function; Conference, Washington, D C , Usa, May 8-10, 1987 Xiii+391p Birkhaeuser Boston, Inc : New York, New York, Usa; Basel, Switzerland Illus 373-376, 1988

Comparison of temporal perception of fruitiness in model systems sweetened with aspartame, an aspartame + acesulfame K blend, or sucrose. Journal of food science: an official ication of the Institute of Food Technologists 56(3): 823-826, 1991

Comparison of temporal perception of fruitiness in model systems sweetened with aspartame an aspartame plus acesulfame k blend or sucrose. Journal of Food Science 56(3): 823-826, 1991

Chrono pharmaco kinetics of aspartame phenyl alaninemia following repeated oral doses of aspartame to normal human subjects. Federation Proceedings 40(3 PART 1): 641, 1981

Method for preparing salts of aspartame from N-protected aspartame. Official Gazette of the United States Patent & Trademark Office Patents 1247(2), June 12, 2001

Interaction of aspartame with selected hydrocolloids: Solubility of aspartame. Food Hydrocolloids 13(4): 299-302, July, 1999

Determination of aspartame and its degradation product diketopiperazine in desserts by high performance liquid chromatography investigations on heat stability of aspartame. Zeitschrift fuer Lebensmittel-Untersuchung und -Forschung 193(4): 344-346, 1991