+ Site Statistics
References:
54,258,434
Abstracts:
29,560,870
PMIDs:
28,072,757
+ Search Articles
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ PDF Full Text
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Translate
+ Recently Requested

Coronary heart disease risk reduction in postmenopausal women: the role of statin therapy and hormone replacement therapy



Coronary heart disease risk reduction in postmenopausal women: the role of statin therapy and hormone replacement therapy



Preventive Cardiology 7(3): 131-136



The incidence of coronary heart disease in women rises sharply in the years following menopause, and prescribing of hormone replacement therapy in the belief that it might compensate for the loss of estrogen-mediated cardioprotection is widespread. However, controlled trials have failed to show a beneficial effect of hormone replacement therapy on the incidence of coronary events, and recent evidence suggests that hormone replacement therapy may even have a deleterious effect on primary coronary heart disease prevention. Statins are recommended as first-line treatment for lowering low-density lipoprotein cholesterol levels in women and are extremely valuable in reducing coronary heart disease risk in this group. An awareness of the benefits of appropriate statin treatment, and evidence showing that they can be safely added to hormone replacement therapy prescribed for the relief of menopausal symptoms and osteoporosis, provides the opportunity to optimize clinical outcomes for coronary heart disease among the large and expanding population of postmenopausal women.

(PDF emailed within 0-6 h: $19.90)

Accession: 048666719

Download citation: RISBibTeXText

PMID: 15249765

DOI: 10.1111/j.1520-037x.2004.3313.x


Related references

Hormone replacement therapy does not prevent coronary heart disease and is associated with increased overall risk for health of postmenopausal women. Final results of studies on hormone replacement therapy efficacy in frame of Women's Health Initiative and data from other recent studies. Kardiologiia 43(9): 77-79, 2004

Hormone Replacement Therapy in Postmenopausal Women: Does It Lessen Coronary Heart Disease Risk?. American Journal of Geriatric Cardiology 5(5): 71-76, 1996

Blood pressure control and hormone replacement therapy in postmenopausal women at risk for coronary heart disease. American Heart Journal 143(4): 711-717, 2002

A Randomized Trial of Oral Contraceptive and Hormone Replacement Therapy on Bone Mineral Density and Coronary Heart Disease Risk Factors in Postmenopausal Women. Obstetrics & Gynecology 95(1): 87-94, 2000

A randomized trial of oral contraceptive and hormone replacement therapy on bone mineral density and coronary heart disease risk factors in postmenopausal women. Obstetrics & Gynecology 95(1): 87-94, 2000

Lipids, hormone replacement therapy, and diet Coronary heart disease in postmenopausal women. Messerli, F H Hypertension in postmenopausal women 149-172, 1996

Postmenopausal hormone-replacement therapy, plasma lipoprotein[a], and risk for coronary heart disease. Journal of Laboratory and Clinical Medicine 123(6): 800-803, 1994

Hormone replacement therapy in postmenopausal women with specific risk factors for coronary artery disease. Maturitas 30(1): 27-36, Sept 20, 1998

Endothelial function is preserved in postmenopausal women on hormone replacement therapy at risk for coronary disease. Circulation 94(8 SUPPL ): I279, 1996

Postmenopausal hormone replacement therapy, lipoprotein and coronary heart disease events in a cohort of 2,853 healthy women. Circulation 102(18 Suppl.): II 837, October 31, 2000

Hormone replacement therapy in postmenopausal women with heart disease and risk for gallstones that require surgery. Annals of Internal Medicine 135(7): S-44, 2001

Estrogen replacement therapy is underutilized among postmenopausal women at high risk for coronary heart disease. American Journal of the Medical Sciences 320(2): 124-127, 2000

Femoral atherosclerosis estrogen replacement therapy and coronary heart disease risk factors in postmenopausal women. Clinical Research 42(1): 40A, 1994

The relation of postmenopausal hormone therapy to serum uric acid and the risk of coronary heart disease events: the Heart and Estrogen-Progestin Replacement Study (HERS). Annals of Epidemiology 16(2): 138-145, 2005

The choice of hormone replacement therapy or statin therapy in the treatment of hyperlipidemic postmenopausal women. Atherosclerosis Suppl.s 3(1): 53-63, 2002