+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Coronavirus-induced demyelination occurs in the absence of CD28 costimulatory signals



Coronavirus-induced demyelination occurs in the absence of CD28 costimulatory signals



Journal of Neuroimmunology 146(1-2): 140-143



Infection of mice with mouse hepatitis virus (MHV) strain A59 results in acute encephalitis, hepatitis, and chronic demyelinating disease. T lymphocytes play an important role in MHV infection, and costimulatory signals are an important component of T cell function. To elucidate the role of the main costimulatory molecule, CD28, in MHV pathogenesis and demyelination, we examined the kinetics of MHV-A59 infection in CD28 knockout mice. MHV-A59-infected CD28 knockout mice developed acute encephalitis and hepatitis, and the same degree of chronic demyelination as normal C57Bl/6 (B6) mice. Thus, CD28, the costimulatory T cell molecule, is not required for MHV infection and MHV-induced demyelination.

Please choose payment method:






(PDF emailed within 1 workday: $29.90)

Accession: 048667178

Download citation: RISBibTeXText

PMID: 14698856


Related references

Coronavirus-induced demyelination occurs in the absence of inducible nitric oxide synthase. Journal of Virology 74(16): 7683-7686, 2000

Coronavirus-induced demyelination occurs in the presence of virus-specific cytotoxic T cells. Virology 200(2): 733-743, 1994

CD28 delivers costimulatory signals for superantigen-induced activation of APC-depleted human T lymphocytes. Abstracts of the General Meeting of the American Society for Microbiology 93: 150, 1993

CD28 delivers costimulatory signals for superantigen-induced activation of antigen-presenting cell-depleted human T lymphocytes. Journal of Immunology 150(8 Pt 1): 3207-3214, 1993

Immunosuppression through blockade of CD28:B7-mediated costimulatory signals. Immunologic Research 15(1): 38-49, 1996

CD28 function: A balance of costimulatory and regulatory signals. Journal of Clinical Immunology 22(1): 1-7, 2002

Simultaneous blockade of costimulatory signals CD28-CD80 and CD40-CD154 combined with monoclonal antibody against CD25 induced a stable chimerism and tolerance without graft-versus-host disease in rat. European Surgical Research. Europaische Chirurgische Forschung. Recherches Chirurgicales Europeennes 46(3): 109-117, 2011

Antibody-induced CD3-CD4 coligation inhibits TCR/CD3 activation in the absence of costimulatory signals in normal mouse CD4(+) T lymphocytes. Cellular Immunology 195(2): 96, 1999

CD28 delivers costimulatory signals independently of its association with phosphatidylinositol 3-kinase. Journal of Immunology 155(10): 4702-4710, 1995

Axonal damage is T cell mediated and occurs concomitantly with demyelination in mice infected with a neurotropic coronavirus. Journal of Virology 75(13): 6115-6120, 2001

Homeostatic expansion occurs independently of costimulatory signals. Journal of Immunology 167(10): 5664-5668, 2001

B7-CD28 costimulatory signals control the survival and proliferation of murine and human γδ T cells via IL-2 production. Journal of Immunology 189(3): 1202-1208, 2012

B7-cd28 costimulatory signals control the survival and proliferation of murine and human gammadelta t cells via il-2 production. 2012

CD28 costimulatory signals in T lymphocyte activation: Emerging functions beyond a qualitative and quantitative support to TCR signalling. Cytokine and Growth Factor Reviews 28: 11-19, 2016