Cutaneous T-cell lymphoma with HTLV-i infection: clinical overlap with adult T-cell leukemia/lymphoma

Sakamoto, F.H.; Colleoni, G.W.B.; Teixeira, S.P.; Yamamoto, M.; Michalany, N.S.; Almeida, F.A.; Chiba, A.K.; Petri, V.; Fernandes, M.A.; Pombo-de-Oliveira, M.S.

International Journal of Dermatology 45(4): 447-449

2006


ISSN/ISBN: 0011-9059
PMID: 16650175
DOI: 10.1111/j.1365-4632.2006.02687.x
Accession: 048699342

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Abstract
Adult T-cell leukemia/lymphoma (ATLL) is a malignant proliferation of mature helper T lymphocytes,(1) and is caused by human T-lymphotropic virus type I (HTLV-I);(2) an HTLV-I infection endemic in the Caribbean, south-western Japan, South America and Africa.(3,4) Seroepidemiological studies suggest that it is also endemic in Brazil.(5) Although carriers of HTLV-I show polyclonal integration of virus in T lymphocytes, only patients with ATLL of various subtypes show monoclonal integration of HTLV-I in tumor cells.(6,7) Cutaneous T-cell lymphomas (CTCL) are a group of primary cutaneous lymphoproliferative diseases(8) with unknown etiology.(9) The two most common presentations of CTCL are mycosis fungoides (MF) and Sézary syndrome (SS).(10-13) However, both CTCL categories can easily resemble ATLL. Therefore, in HTLV-I endemic areas, differentiation between ATLL and CTCL must be performed, as they have different prognoses and treatment approaches.(14).

Cutaneous T-cell lymphoma with HTLV-i infection: clinical overlap with adult T-cell leukemia/lymphoma