+ Site Statistics
References:
54,258,434
Abstracts:
29,560,870
PMIDs:
28,072,757
+ Search Articles
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ PDF Full Text
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Translate
+ Recently Requested

Delayed radiation necrosis with extensive brain edema after gamma knife radiosurgery for multiple cerebral cavernous malformations--case report



Delayed radiation necrosis with extensive brain edema after gamma knife radiosurgery for multiple cerebral cavernous malformations--case report



Neurologia Medico-Chirurgica 43(8): 391-395



A 39-year-old man presented with multiple intracranial cavernous malformations manifesting as intractable seizures persisting for more than 20 years. He underwent gamma knife radiosurgery (GKRS) for right frontal and left temporal cavernous malformations. He began to suffer from progressive left hemiparesis and inattention 2 years 5 months after the GKRS. Magnetic resonance imaging showed abnormal ring enhancement and extensive brain edema around the right frontal lesion. Conservative therapies such as external decompression, low-dose barbiturates, and mild hypothermia had no effect on his clinical status. Stereotactic biopsy of the ring-enhanced area demonstrated gliosis. Signs of cerebral herniation appeared, so we performed partial resection of the right frontal lobe. His symptoms recovered immediately. Subsequent hyperbaric oxygen (HBO) therapy significantly improved the extensive brain edema. Delayed radiation necrosis associated with potentially fatal brain edema may occur after GKRS for cavernous malformations. Internal decompression and subsequent HBO therapy were very effective for the treatment of these lesions.

(PDF emailed within 0-6 h: $19.90)

Accession: 048727386

Download citation: RISBibTeXText

PMID: 12968806

DOI: 10.2176/nmc.43.391


Related references

A case of multiple cerebral arteriovenous malformations treated by gamma knife radiosurgery. No Shinkei Geka. Neurological Surgery 23(12): 1121-1125, 1995

Histopathology of radiation necrosis with severe peritumoral edema after gamma knife radiosurgery for parasagittal meningioma. A report of two cases. Stereotactic and Functional Neurosurgery 85(6): 292-295, 2007

Brain Edema after Repeat Gamma Knife Radiosurgery for a Large Arteriovenous Malformation: A Case Report. Experimental Neurobiology 25(4): 191-196, 2016

Radiation-induced cavernous malformation at the site of arteriovenous malformation following gamma knife radiosurgery: case report. Clinical Neurology and Neurosurgery 114(9): 1287-1289, 2013

Symptomatic radiation necrosis 10 years after gamma knife surgery for arteriovenous malformations: a case report. Brain and Nerve 62(5): 539-543, 2010

Radiation-induced intratumoral necrosis and peritumoral edema after gamma knife radiosurgery for intracranial meningiomas. Journal of Korean Neurosurgical Society 52(2): 98-102, 2012

CT of undue radiation effects in cerebral arteriovenous malformations treated by gamma knife radiosurgery. Neuroradiology 34(SUPPL ): S23, 1992

Low-Dose Gamma Knife (GK) Radiosurgery Plus Whole-Brain Radiation Therapy (WBRT) Versus GK Alone for Multiple Brain Metastases: A Matched Case-Control Study. International Journal of Radiation Oncology*biology*physics 90(1): S308-S309, 2014

Gamma knife radiosurgery for cavernous malformations. Zhongguo Yi Xue Ke Xue Yuan Xue Bao. Acta Academiae Medicinae Sinicae 27(1): 18-21, 2005

Hypertrophic olivary degeneration following surgical resection or gamma knife radiosurgery of brainstem cavernous malformations: an 11-case series and a review of literature. Acta Neurochirurgica 155(3): 469-476, 2013

Gamma Knife Radiosurgery of Brainstem Cavernous Malformations. Stereotactic and Functional Neurosurgery 94(6): 397-403, 2016

Gamma knife radiosurgery for intracranial cavernous malformations. Clinical Neurology and Neurosurgery 112(6): 474-477, 2010

Gamma knife radiosurgery for brainstem cavernous malformations. Clinical Neurology and Neurosurgery 151: 55-60, 2016

Gamma knife radiosurgery-induced cavernous hemangioma: case report. Neurosurgery 64(5): E1006-7; Discussion E1007, 2009

Significant Hemorrhage Rate Reduction after Gamma Knife Radiosurgery in Symptomatic Cavernous Malformations: Long-Term Outcome in 95 Case Series and Literature Review. Stereotactic and Functional Neurosurgery 95(6): 369-378, 2017