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Deoxyribozyme-based ligase logic gates and their initial circuits

Stojanovic, M.N.; Semova, S.; Kolpashchikov, D.; Macdonald, J.; Morgan, C.; Stefanovic, D.

Journal of the American Chemical Society 127(19): 6914-6915

2005


ISSN/ISBN: 0002-7863
PMID: 15884910
DOI: 10.1021/ja043003a
Accession: 048734562

A complete set (YES, NOT, AND, and ANDNOT) of molecular scale logic gates based on ligase deoxyribozymes was constructed. The activity of these gates was visualized through the formation of cascades with downstream phosphodieseterase YES gates, which performed fluorogenic cleavage.

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