Detection of chromosome 8 anomalies in ovarian carcinoma by fluorescence in situ hybridization
Dong, Y.-l.; Li, C.-h.; Chen, L.-x.; Feng, H.-y.; Zhu, B.-s.
Zhonghua Yi Xue Yi Chuan Xue Za Zhi 20(1): 59-60
2003
ISSN/ISBN: 1003-9406 PMID: 12579504 Accession: 048745158
To detect the relationship between chromosomal anomalies and the pathogenesis, development and prognosis of ovarian carcinoma. Thirty-six specimens of ovarian carcinoma (n=12), ovarian benign tumor (n=12), and normal ovary (n=12) were examined by fluorescence in situ hybridization (FISH). Twelve cases of mutations, including trisomy 8, monosomy 8 or tetraploid 8 chromosomal anomalies, were found in the group of ovarian carcinoma, making up 100% (12/12). Three cases of trisomy 8 chromosomal anomalies were found in the group of ovarian benign tumor, accounting for 25% (3/12). No anomaly was found in the normal group. There were significant differences between the three groups, P<0.001. The above anomalies of chromosome 8 are significantly associated with the pathogenesis and development of ovarian carcinoma. The anomalies may occur in the early stage of the carcinoma, and may be significantly associated with the pathological differentiation and clinical stage of the case.