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Diastereoselective amplification of an induced-fit receptor from a dynamic combinatorial library



Diastereoselective amplification of an induced-fit receptor from a dynamic combinatorial library



Journal of the American Chemical Society 127(25): 8902-8903



A high-affinity, induced-fit receptor for NMe4I was discovered using dynamic combinatorial chemistry. The addition of the guest to a dynamic combinatorial library made using a racemic mixture of chiral building blocks caused the strong and highly diastereoselective amplification of the receptor at the expense of other library components. The receptor and its mode of binding were characterized by NMR, ITC, and re-equilibration experiments, from which it was deduced that the receptor probably forms a folded four-stave barrel shape on binding of the guest.

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Accession: 048782243

Download citation: RISBibTeXText

PMID: 15969538

DOI: 10.1021/ja050790i


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