+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Effect of SARS-associated coronavirus on peripheral blood picture and liver function



Effect of SARS-associated coronavirus on peripheral blood picture and liver function



Zhongguo Wei Zhong Bing Ji Jiu Yi Xue 16(11): 660-663



To study peripheral blood picture and liver function of severe acute respiratory syndrome (SARS), and to accumulate more experience in prevention and treatment this syndrome. The peripheral blood picture and liver function of 169 cases with SARS were analyzed. These patients were admitted to five hospitals in Taiyuan from March to May, 2003. Above 90.00% patients had normal or low white blood cell (WBC) count on the first day. From then on, during the second to third week, about 40.00% of the patients showed high WBC count average: (13.42+/-2.87)x10(9)/L at 15 th day and (13.68+/-3.26)x10(9)/L at 21 st day) and neutrophil (0.809+/-0.063 at 15 th day and 0.805+/-0.061 at 21 st day), and 21.97%-52.15% cases with low lymphocyte count (0.111+/-0.044-0.134+/-0.040). About 4.44%-12.76% of patients developed low platelet and 4.20%-33.33% of cases with low hemoglobin level. And 32.76%-62.50% of cases were found to have high alanine aminotransferase (above 40 U/L), 13.04%-40.00% cases with high aspartate aminotransferase (above 40 U/L) and 40.35%-72.00% cases with low albumin content. But serum total protein remained normal during the whole clinical course. SARS cases may develop leucocytosis, low lymphocyte count, low platelet count, low hemoglobin level and abnormal liver function.

Please choose payment method:






(PDF emailed within 1 workday: $29.90)

Accession: 048865375

Download citation: RISBibTeXText

PMID: 15535899


Related references

SARS-coronavirus replicates in mononuclear cells of peripheral blood (PBMCs) from SARS patients. Journal of Clinical Virology 28(3): 239-244, 2003

Differential sensitivities of severe acute respiratory syndrome (SARS) coronavirus spike polypeptide enzyme-linked immunosorbent assay (ELISA) and SARS coronavirus nucleocapsid protein ELISA for serodiagnosis of SARS coronavirus pneumonia. Journal of Clinical Microbiology 43(7): 3054-3058, 2005

An overall picture of SARS coronavirus (SARS-CoV) genome-encoded major proteins: structures, functions and drug development. Current Pharmaceutical Design 12(35): 4539-4553, 2006

Effects of severe acute respiratory syndrome (SARS) coronavirus infection on peripheral blood lymphocytes and their subsets. International Journal of Infectious Diseases 9(6): 323-330, 2005

Detection and monitoring of SARS coronavirus in the plasma and peripheral blood lymphocytes of patients with severe acute respiratory syndrome. Clinical Chemistry 50(7): 1237-1240, 2004

Dynamic changes of serum SARS-coronavirus IgG, pulmonary function and radiography in patients recovering from SARS after hospital discharge. Respiratory Research 6: 5, 2005

Mutagenesis of the transmembrane domain of the SARS coronavirus spike glycoprotein: refinement of the requirements for SARS coronavirus cell entry. Virology Journal 6: 230, 2009

Alisporivir inhibits MERS- and SARS-coronavirus replication in cell culture, but not SARS-coronavirus infection in a mouse model. Virus Research 228: 7, 2017

Evidence of the recombinant origin of a bat severe acute respiratory syndrome (SARS)-like coronavirus and its implications on the direct ancestor of SARS coronavirus. Journal of Virology 82(4): 1819-1826, 2008

Development of a quantitative assay for SARS coronavirus and correlation of GAPDH mRNA with SARS coronavirus in clinical specimens. Journal of Clinical Pathology 58(3): 276-280, 2005

Difference in receptor usage between severe acute respiratory syndrome (SARS) coronavirus and SARS-like coronavirus of bat origin. Journal of Virology 82(4): 1899-1907, 2008

Mouse studies of SARS coronavirus-specific immune responses to recombinant replication-defective adenovirus expressing SARS coronavirus N protein. Hong Kong Medical Journal 15(Suppl. 2): 33-36, 2009

Detection of specific antibodies to severe acute respiratory syndrome (SARS) coronavirus nucleocapsid protein for serodiagnosis of SARS coronavirus pneumonia. Journal of Clinical Microbiology 42(5): 2306-2309, 2004

Severe Acute Respiratory Syndrome (SARS) Coronavirus ORF8 Protein Is Acquired from SARS-Related Coronavirus from Greater Horseshoe Bats through Recombination. Journal of Virology 89(20): 10532-10547, 2015