EurekaMag
+ Most Popular
Cunninghamia lanceolata plantations in China
Mammalian lairs in paleo ecological studies and palynology
Studies on technological possibilities in utilization of anhydrous milk fat for production of recombined butter-like products
Should right-sided fibroelastomas be operated upon?
Large esophageal lipoma
Apoptosis in the mammalian thymus during normal histogenesis and under various in vitro and in vivo experimental conditions
Poissons characoides nouveaux ou non signales de l'Ilha do Bananal, Bresil
Desensitizing efficacy of Colgate Sensitive Maximum Strength and Fresh Mint Sensodyne dentifrices
Administration of fluid by subcutaneous infusion: revival of a forgotten method
Tundra mosquito control - an impossible dream?
Schizophrenia for primary care providers: how to contribute to the care of a vulnerable patient population
Geochemical pattern analysis; method of describing the Southeastern limestone regional aquifer system
Incidence of low birth weights in a hospital of Mexico City
Tabanidae
Graded management intensity of grassland systems for enhancing floristic diversity
Microbiology and biochemistry of cheese and fermented milk
The ember tetra: a new pygmy characid tetra from the Rio das Mortes, Brazil, Hyphessobrycon amandae sp. n. (Pisces, Characoidei)
Risk factors of contrast-induced nephropathy in patients after coronary artery intervention
Renovation of onsite domestic wastewater in a poorly drained soil
Observations of the propagation velocity and formation mechanism of burst fractures caused by gunshot
Systolic blood pressure in a population of infants in the first year of life: the Brompton study
Haematological studies in rats fed with metanil yellow
Studies on pasteurellosis. I. A new species of Pasteurella encountered in chronic fowl cholera
Dormancy breaking and germination of Acacia salicina Lindl. seeds
therapy of lupus nephritis. a two-year prospective study

Effect of penetration enhancers on the transdermal delivery of bupranolol through rat skin


Effect of penetration enhancers on the transdermal delivery of bupranolol through rat skin



Drug Delivery 12(3): 165-169



ISSN/ISBN: 1071-7544

PMID: 16025846

DOI: 10.1080/10717540590931936

Bupranolol (BPL) is a suitable drug candidate for transdermal drug delivery system development based on its favorable physicochemical and pharmacokinetic properties. The effect of different penetration enhancers on the permeation of BPL across rat skin was studied using side-by-side diffusion cells. 2-Pyrrolidone (PY), 1-methyl-2-pyrrolidone (MPY), and propylene glycol (PG) at various concentrations were used as penetration enhancers along with 0.4% w/v aqueous suspension of BPL. Menthol at different concentrations in isopropanol-water (6:4) mixture also was used as an enhancer wherein BPL at 0.4% w/v was completely solubilized. Skin pretreatment studies were carried out with all the above enhancers to understand their role in the penetration enhancement effect. PY and MPY at 5% w/v concentrations increased the permeation of BPL by 3.8- and 2.4-fold, respectively, versus control (p < .01). PG at 10% and 30 w/v concentrations increased the flux of BPL by 2.5- and 5.0-fold, respectively, versus control (p < .001). Menthol at 2% w/v concentration increased the flux of BPL by 3.8-fold (p < .01) and further increase in menthol concentration significantly decreased the flux of BPL. Overall, pyrrolidones and menthol at low concentrations (5% w/v or less) and PG at 30% w/v concentration were effective as penetration enhancers for BPL.

Please choose payment method:






(PDF emailed within 0-6 h: $19.90)

Accession: 048885189

Download citation: RISBibTeXText

Related references

Effect of penetration enhancers on the release and skin permeation of bupranolol from reservoir-type transdermal delivery systems. International Journal of Pharmaceutics 288(2): 325-334, 2005

The effect of skin penetration enhancers on the transdermal delivery of pyridostigmine bromide. Drug Development and Industrial Pharmacy 15(11): 1855-1864, 1989

Effect of Penetration Enhancers and Safety on the Transdermal Delivery of Apremilast in Skin. Pharmaceutics 14(5), 2022

In vitro evaluation of transdermal albuterol delivery systems with skin penetration enhancers. Pharmaceutical Research (New York) 9(10 Suppl): S194, 1992

Synthesis and effect of two new penetration enhancers on the transdermal delivery of 5-fluorouracil through excised rat skin. Chemical and Pharmaceutical Bulletin 46(9): 1428-1431, 1998

Enhanced delivery of 5 fluorouracil through shed snake skin by two new transdermal penetration enhancers. Pharmaceutical Research (New York) 8(10 Suppl): S138, 1991

Enhanced delivery of 5-fluorouracil through shed snake skin by two new transdermal penetration enhancers. International Journal Of Pharmaceutics (amsterdam). 92(1-3): 89-95, 1993

Recent Advances in Skin Penetration Enhancers for Transdermal Gene and Drug Delivery. Current Gene Therapy 17(2): 139-146, 2017

Screening of chemical penetration enhancers for transdermal drug delivery using electrical resistance of skin. Pharmaceutical Research 25(11): 2697-2704, 2008

Effect of vehicle and penetration enhancers on transdermal delivery of methotrexate through hairless mouse skin. Pharmaceutical Research (New York) 12(9 Suppl): S274, 1995

The Pretreatment Effect of Chemical Skin Penetration Enhancers in Transdermal Drug Delivery Using Iontophoresis. Skin Pharmacology and Physiology 12(6): 326-335, 1999

The pretreatment effect of chemical skin penetration enhancers in transdermal drug delivery using iontophoresis. Skin Pharmacology and Applied Skin Physiology 12(6): 326-335, 1999

Effects of solvents and penetration enhancers on transdermal delivery of thymoquinone: permeability and skin deposition study. Drug Delivery 25(1): 1943-1949, 2018

Enhancement of transdermal delivery of progesterone using medium-chain mono and diglycerides as skin penetration enhancers. Pharmaceutical Development and Technology 14(5): 524-529, 2009

Transdermal delivery of the tetrapeptide Hisetal (melanotropin (6-9)): II. Effect of various penetration enhancers. In vitro study across human skin. International Journal of Pharmaceutics (Amsterdam) 103(1): 77-80, 1994