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Effects of benzodiazepines on enzymes metabolizing drugs. IV. Effect of diazepam and oxazepam on hepatic microsomal drug metabolizing enzymes in rats exposed to high environmental temperature

Pachecka, J.; Kobylińska, K.; Zagdańska, B.; Zasłona, H.; Bicz, W.

Acta Poloniae Pharmaceutica 47(1-2): 23-26

1990

ISSN/ISBN: 0001-6837
PMID: 12959254
Accession: 048904109
Administration of diazepam or oxazepam caused a different response of the rat hepatic microsomal cytochrome P-450 dependent monooxygenase system. Both drugs produced significant decrease in the activity of NADH: cytochrome c oxidoreductase in rats exposed to 21 degrees C, but not to 28 degrees C and 35 degrees C, and did not change the activity of aniline hydroxylase, aminopyrine N-demethylase and 4-nitroanisole O-demethylase and cytochrome b5 level at any tested temperatures. Oxazepam, but not diazepam, caused a decrease in cytochrome P-450 content in rats exposed to 21 degrees C only. The results indicate that the high ambient temperature modifies the effect of tested benzodiazepines on the activity of some microsomal enzymes.

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Related References

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