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Effects of interleukin on orbital fibroblasts of patients with Graves' ophthalmopathy



Effects of interleukin on orbital fibroblasts of patients with Graves' ophthalmopathy



Sichuan Da Xue Xue Bao. Yi Xue Ban 35(2): 241-243



To observe the effects of interleukin including interleukin (IL)-1, interleukin (IL)-2, interleukin (IL)-6 on proliferation of orbital fibroblasts (OFs) and on secretion of hyaluronic acid (HA) in vitro. OFs from 5 patients with Graves' ophthalmopathy (GO) and from 4 normal control subjects were cultured in vitro. IL-1, IL-2, IL-6 with different concentrations were incubated with cultured OFs. The proliferation of OFs and the production of HA were measured by MTT and radioimmunological technique. IL-1 (5, 50, 500 U/ml), IL-2 (500 U/ml) and IL-6 (500 U/ml) could significantly stimulate the proliferation of OFs and the secretion of HA. At the concentration of 500 U/ml, IL-1 had stimulating effects on patients' OFs more than on normal subjects' OFs. IL-1, IL-2, IL-6 can stimulate proliferation of OFs and secretion of HA. The disturbance of interleukin may be one aspect of the pathogenesis of GO.

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Accession: 048909759

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PMID: 15071929


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