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Evaluation of O-[11C]methyl-L-tyrosine and O-[18F]fluoromethyl-L-tyrosine as tumor imaging tracers by PET



Evaluation of O-[11C]methyl-L-tyrosine and O-[18F]fluoromethyl-L-tyrosine as tumor imaging tracers by PET



Nuclear Medicine and Biology 31(2): 191-198



We investigated the potential of O-[(11)C]methyl-L-tyrosine and O-[(18) F]fluoromethyl-L-tyrosine as positron-emitting tracers for tumor imaging. The two tracers had similar distribution patterns in rats bearing AH109A hepatoma, with pancreas and, on a lesser extent, AH109A showing the highest uptake. Uptake of both tracers in the AH109A and uptake ratios of AH109A-to-tissues (with the exception of AH109A-to-bone) gradually increased for 60 min. O-[(11)C]methyl-L-tyrosine was metabolically stable, whereas a negligible low amount of metabolites was observed for O-[(18)F]fluoromethyl-L-tyrosine. Both tracers showed the potential for tumor imaging.

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Accession: 048993014

Download citation: RISBibTeXText

PMID: 15013484

DOI: 10.1016/j.nucmedbio.2003.07.004


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