+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Evaluation of WordNet as a source of lay knowledge for molecular biology and genetic diseases: a feasibility study

Evaluation of WordNet as a source of lay knowledge for molecular biology and genetic diseases: a feasibility study

Studies in Health Technology and Informatics 95: 379-384

While several sources of biomedical knowledge are available, these resources are often highly specialized and usually not suitable for a lay audience. This paper evaluates whether concepts needed for molecular biology and genetic diseases are present in WordNet, the electronic lexical database. Terms for four broad categories of concepts (phenotype, molecular function, biological process, and cellular component) were extracted from LocusLink and mapped to WordNet. All terms from the Gene Ontology database (gene products and ontology concepts) were also mapped to WordNet in order to evaluate its global coverage of the domain. Additionally, we tested two methods for improving the mapping of genetic disease names to WordNet. The coverage of concepts ranged from 0% (gene product symbols) to 2.8% (cellular components). Removing specialization markers from the terms and using synonyms significantly increased the rate of mapping of genetic disease names to WordNet. Many of the most common single gene disorders are present in WordNet, as well as many high-level concepts in Gene Ontology. Therefore, WordNet is likely to be a useful source of lay knowledge in the framework of a consumer health information system on genetic diseases.

Please choose payment method:

(PDF emailed within 1 workday: $29.90)

Accession: 048993171

Download citation: RISBibTeXText

PMID: 14664016

Related references

Knowledge discovery and system biology in molecular medicine: an application on neurodegenerative diseases. In Silico Biology 5(2): 199-208, 2005

Using WordNet synonym substitution to enhance UMLS source integration. Artificial Intelligence in Medicine 46(2): 97, 2009

Genetic osteoarticular diseases under the molecular biology spotlight. Joint Bone Spine 71(6): 486-492, 2004

Molecular biology of genetic diseases--lessons from thalassemias. Fukuoka Igaku Zasshi 84(4): 121-126, 1993

Assessment of knowledge of participants on basic molecular biology techniques after 5-day intensive molecular biology training workshops in Nigeria. Biochemistry and Molecular Biology Education 45(4): 313-317, 2017

Evaluation of the pain matrix using EEG source localization: a feasibility study. Pain Medicine 12(8): 1241-1248, 2011

Neurosurgery and molecular biology: (series 1) basic knowledge for understanding molecular biology of the cell. No Shinkei Geka. Neurological Surgery 26(3): 200-206, 1998

Molecular biology and genetic engineering: new prospects for control of viral diseases of plants. Comptes Rendus de l' Academie d' Agriculture de France 83(1): 153-160, 1997

Molecular biology and genetic engineering: New prospects about the control of viral diseases of plants. Comptes Rendus de l'Academie d'Agriculture de France 83(1): 153-160, 1997

Peroxisomes: biochemistry, molecular biology and genetic diseases- a video programme for teaching students. Biochemical Education 28(3): 136-138, 2000

Molecular Biology of Prion Diseases || Genetic Analysis of Creutzfeldt-Jakob Disease and Related Disorders. Philosophical Transactions Biological Sciences 343(1306): 379-384, 1994

Molecular biology in malignant blood diseases. Clinical applications. Study of immunoglobulin and T-cell receptor genes and molecular analysis of the translocations. Sangre 41(4): 321-334, 1996

Molecular Biology of Human Genetic Disease. Keystone Symposia on Molecular and Cellular Biology. April 3-10, 1992. Abstracts. Journal of Cellular Biochemistry. Suppl. 16f: 1-29, 1992

FEBS Advanced Course on Peroxisomes, Biochemistry, Molecular Biology and Genetic Diseases, Dijon, France, April 25-27, 1993. Biochimie 75(3-4): 143-315, 1993

Feasibility study for a microchip-based approach for noninvasive prenatal diagnosis of genetic diseases. Annals of the new York Academy of Sciences 1022: 105-112, 2004