+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Expression of GDNF in dorsal root ganglion after partial dorsal root rhizotomy and acupuncture in spared root



Expression of GDNF in dorsal root ganglion after partial dorsal root rhizotomy and acupuncture in spared root



Sichuan Da Xue Xue Bao. Yi Xue Ban 34(2): 245-247



Investigating the expression of glial cell line-derived neurotrophic factor (GDNF) in dorsal root ganglion after partial dorsal root rhizotomy and acupuncture in spared root. Fifteen adult cats were divided into three groups. Two groups were subjected to unilateral spared root rhizotomy (L1-L5, L7-S2 DRGs were sectioned, L6 DRG was spared). In one of these operating groups, two sets of acupoints (Zusanli and Xuanzhong; Futu and Sanyinjiao) located in the distribution area of spinal nerve L6 were electro-stimulated alternatively 30 min everyday by electro-needling. The other operation group was not treated with acupuncture. On the 7th day after partial dorsal rhizotomy and acupuncture, the animals of these two groups and another group (intact animals as reference group) were sacrificed. The DRGs (L6) were taken and made into frozen sections and were stained under the same condition using specific GDNF antibody (1:1000) by ABC method. The GDNF positive large, medium and small sized neurons in DRG were counted. In intact animals, about 55% neurons, including large sized neurons (25%) and a few small (16%) and medium sized neurons (14%), were stained. In contrast, at 7 days after partial dorsal root rhizotomy, the numbers of positive neurons decreased greatly (35%) more than that of reference group (P < 0.05). However, following acupuncture, about 90% neurons, including large (28%) medium (17%) and small (45%) neurons, came to be stained again. The number of GDNF positive large neurons decreased greatly at 7 days following partial dorsal root rhizotomy, but increased greatly after acupuncture. In addition, the number of GDNF positive small neurons increased greatly after acupuncture (P < 0.05).

Please choose payment method:






(PDF emailed within 1 workday: $29.90)

Accession: 049042436

Download citation: RISBibTeXText

PMID: 12947701


Related references

C-jun expression in spared dorsal root ganglion following partial dorsal root rhizotomy and acupuncture. Sichuan Da Xue Xue Bao. Yi Xue Ban 34(2): 248-250, 2003

Effect of partial dorsal root rhizotomy on expression of GDNF and FGF-2 in spared dorsal root ganglia. Sichuan Da Xue Xue Bao. Yi Xue Ban 36(4): 480-483, 2005

Effects of electro-acupuncture on PDGF expression in spared dorsal root ganglion and associated dorsal horn subjected to partial dorsal root ganglionectomy in cats. Neurochemical Research 33(3): 437-443, 2008

Expression of Sema3A and NP-1 in spinal cord and spared dorsal root ganglion after partial dorsal root rhizotomy of cat. Sichuan Da Xue Xue Bao. Yi Xue Ban 39(1): 48-51, 2008

Expression of CNTF and PDGF in spared dorsal root ganglion after partial dorsal root rhizotomy. Sichuan Da Xue Xue Bao. Yi Xue Ban 36(2): 176-179, 2005

Expression of Bax, Bcl-2 and caspase-3 in spared dorsal root ganglion after partial dorsal root rhizotomy. Sichuan Da Xue Xue Bao. Yi Xue Ban 36(2): 180-183, 2005

The changes of NT-4 expression in spared root ganglion and spinal cord following partial dorsal root rhizotomy. Sichuan Da Xue Xue Bao. Yi Xue Ban 36(1): 35-38, 2005

The influence of partial dorsal root rhizotomy on IGF-I expression in spared root ganglion and spinal cord. Sichuan Da Xue Xue Bao. Yi Xue Ban 36(1): 31-34, 2005

The expression of trkC in spared dorsal root ganglion following unilateral dorsal root rhizotomy. Hua Xi Yi Ke Da Xue Xue Bao 31(3): 328-9 333, 2000

Effects of electro-acupuncture on the expression of c-jun and c-fos in spared dorsal root ganglion and associated spinal laminae following removal of adjacent dorsal root ganglia in cats. Neuroscience 140(4): 1169-1176, 2006

Effects of electro-acupuncture on CNTF expression in spared dorsal root ganglion and the associated spinal lamina II and nucleus dorsalis following adjacent dorsal root ganglionectomies in cats. Neuropeptides 42(1): 95, 2008

Effects of electro-acupuncture on IGF-I expression in spared dorsal root ganglia and associated spinal dorsal horn in cats subjected to adjacent dorsal root ganglionectomies. Neurochemical Research 34(11): 1993-1998, 2009

Changes in PDGF expression in spared dorsal root ganglia and associated spinal dorsal horns in cats subjected to partial dorsal root ganglionectomy. Neuroscience Letters 431(2): 112-117, 2008

Changes in PDGF expression in spared dorsal root ganglia and associated spinal dorsal horns in cats subjected to partial dorsal root ganglionectomy (vol 431, pg 112, 2008). 2007

The neurite-outgrowth promoting effect from Clarke's nucleus of cat spinal cord with spared dorsal root preparation under electro-acupuncture stimulation on dorsal root ganglion of chicken embryo. Sheng Li Ke Xue Jin Zhan 26(4): 333-336, 1995