+ Site Statistics
References:
54,258,434
Abstracts:
29,560,870
PMIDs:
28,072,757
+ Search Articles
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ PDF Full Text
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Translate
+ Recently Requested

Expression of platelet-derived growth factor-alpha alpha receptor is associated with tumor progression in clear cell renal cell carcinoma



Expression of platelet-derived growth factor-alpha alpha receptor is associated with tumor progression in clear cell renal cell carcinoma



American Journal of Clinical Pathology 120(1): 107-112



Platelet-derived growth factors (PDGFs) exert their biologic function by binding to 3 different tyrosine kinase receptor isoforms. Especially the PDGF-alpha alpha receptor binds PDGF proteins with high specificity, which results in growth stimulation. The expression of the receptor and its ligand was studied in human renal cell carcinomas (RCCs) by immunohistochemical analysis, and the expression of PDGF-alpha alpha receptor and PDGF-AA was correlated with clinicopathologic parameters of patients with clear cell RCC (CCRCC). In CCRCC, the mean expression of PDGF-alpha alpha receptor and PDGF-AA was 38.8% (range, 0.0%-96.0%) and 18.4% (range, 0.0%-90.0%), respectively. PDGF-alpha alpha receptor expression was significantly higher in grade 3 and grade 4 tumors compared with grade 1 and grade 2 tumors (P = .027; Mann-Whitney test), and high receptor expression correlated with tumor progression in univariate analysis (P = .0253; log-rank test), while PDGF-AA expression had no prognostic influence on the outcome of patients with CCRCC. Therefore, immunohistochemical detection of high PDGF-alpha alpha receptor expression in CCRCC is associated with adverse outcomes. Furthermore, the PDGF receptor-factor interaction loop may be considered as a possible target for novel therapeutic strategies.

(PDF emailed within 0-6 h: $19.90)

Accession: 049044794

Download citation: RISBibTeXText

PMID: 12866380

DOI: 10.1309/lq9e-mk8q-ke75-nggx


Related references

Expression of Platelet-Derived Growth Factor- Receptor Is Associated With Tumor Progression in Clear Cell Renal Cell Carcinoma. American Journal of Clinical Pathology 120(1): 107-112, 2003

Nuclear expression of hypoxia-inducible factor-1 alpha in clear cell renal cell carcinoma is involved in tumor progression. American Journal of Surgical Pathology 31(12): 1875-1881, 2007

Prognostic significance of platelet-derived growth factor receptor-β expression in localized clear cell renal cell carcinoma. Journal of Cancer Research and Clinical Oncology 141(12): 2213-2220, 2016

Prognostic significance of CD44, platelet-derived growth factor receptor alpha, and cyclooxygenase 2 expression in renal cell carcinoma. Archives of Pathology & Laboratory Medicine 131(2): 261-267, 2007

Prognostic Significance Of Platelet Derived Growth Factor- Receptor In Localized Clear Cell Renal Cell Carcinoma. The Journal of Urology 189(4): e736-e737, 2013

Expression of Ki-67, p53, bcl-2, estrogen receptors alpha in patients with clear cell renal carcinoma and epidermal growth factor receptor mutation. Arkhiv Patologii 73(2): 6-7, 2011

Blocking platelet-derived growth factor-D/platelet-derived growth factor receptor beta signaling inhibits human renal cell carcinoma progression in an orthotopic mouse model. Cancer Research 65(13): 5711-5719, 2005

Platelet-derived growth factor receptor alpha mutational status and immunohistochemical expression in Merkel cell carcinoma: implications. 2008

Overexpression of platelet-derived growth factor receptor alpha promotes tumor progression and indicates poor prognosis in hepatocellular carcinoma. Oncotarget 5(21): 10307-10317, 2015

Low differentiated microvascular density and low expression of platelet-derived growth factor-BB (PDGF-BB) predict distant metastasis and poor prognosis in clear cell renal cell carcinoma. Bju International 112(4): E415-E423, 2013

Expression of epidermal growth factor receptor egfr and transforming growth factor alpha tgf alpha messenger rna in normal kidney and renal cell carcinoma. Journal of Urology 141(4 PART 2): 297A, 1989

Tumor-driven paracrine platelet-derived growth factor receptor alpha signaling is a key determinant of stromal cell recruitment in a model of human lung carcinoma. Clinical Cancer Research 12(9): 2676-2688, 2006

Expression of hypoxia-inducible factor-1-alpha, hypoxia-inducible factor-2alpha and vascular endothelial growth factor in sporadic clear cell renal cell renal cell carcinoma and their significance in the pathogenesis thereof. Zhonghua Yi Xue Za Zhi 86(22): 1526-1529, 2006

Platelet-derived growth factor receptor alpha mutational status and immunohistochemical expression in Merkel cell carcinoma: implications for treatment with imatinib mesylate. Journal of Cutaneous Pathology 35(2): 197-202, 2008

Role of transforming growth factor-alpha in von Hippel--Lindau (VHL)(-/-) clear cell renal carcinoma cell proliferation: a possible mechanism coupling VHL tumor suppressor inactivation and tumorigenesis. Proceedings of the National Academy of Sciences of the United States of America 98(4): 1387-1392, 2001