EurekaMag
+ Translate
+ Most Popular
Gaucher's disease;thirty-two years experience at Siriraj Hospital
A study of Macrobathra Meyrick from China (Lepidoptera, Cosmopterigidae)
First occurrence in ores of tetragonal chalcocite
Effects of trace element nutrition on sleep patterns in adult women
N.Z. range management guidelines. 2. Design of grazing management systems for tussock country
A case of lipoma of the esophagus
A revision of world Acanthosomatidae (Heteroptera: Pentatomidae): keys to and descriptions of subfamilies, tribes and genera, with designation of types
Life history of the coronate scyphozoan Linuche unguiculata (Swartz, 1788)
Perceptual restoration of obliterated sounds
Mutagenicity studies on two chromium(III) coordination compounds
The formation of the skeleton. I. Growth of a long bone. 1st appearance of a center of calcification
Leucopenia and abnormal liver function in travellers on malaria chemoprophylaxis
The joint commission: four key root causes loom large in sentinel event data
Treatment of vitiligo with topical 15% lactic acid solution in combination with ultra violet-A
Behaviour of dairy cows within three hours after feed supply: I. Influence of housing type and time elapsing after feed supply
Observations of the propagation velocity and formation mechanism of burst fractures caused by gunshot
Management and control of patients with type 2 diabetes mellitus in Lebanon: results from the International Diabetes Management Practices Study (IDMPS)
The diet composition and nutritional knowledge of patients with anorexia nervosa
Physoporella croatica Herak, 1958 of the Slovak karst Anisian (Slovakia, the West Carpathians Mts.)
Bright lights, big noise. How effective are vehicle warning systems?
Ein Plesiosaurier-Rest mit Magensteinen aus mittlerem Lias von Quedlinburg
Incidence of Chlamydia trachomatis in patients with sterility
Monster soup: the microscope and Victorian fantasy
Preliminary tests with residual sprays against poultry lice
Duration of the life of plants in phylogeny

Expression of transforming growth factor-alpha and hepatitis B surface antigen in human hepatocellular carcinoma tissues and its significance


Expression of transforming growth factor-alpha and hepatitis B surface antigen in human hepatocellular carcinoma tissues and its significance



World Journal of Gastroenterology 10(6): 830-833



ISSN/ISBN: 1007-9327

PMID: 15040026

To evaluate the expression of transforming growth factor-alpha (TGF-alpha) and hepatitis B surface antigen (HBsAg) in human hepatocellular carcinoma (HCC) tissues and its significance. Seventy specimens of HCC tissues were detected by immunohistochemical method. Five specimens of normal human liver tissues were used as control. The TGF-alpha positive expression rates in HCC and its surrounding tissues were 74.3%(52/70) and 88.1%(52/59), respectively. TGF-alpha positive granules were mainly in the cytoplasm and fewer existed on the karyotheca. The TGF-alpha positive expressing rate in well differentiated HCC was significantly higher than that in moderately and poorly differentiated HCC (P<0.05). The TGF-alpha positive expression also was observed in intrahepatic bile ducts (part of those were hyperplastic ducts). The HBsAg positive expression rates in HCC and its surrounding tissues were 21.4%(15/70) and 79.7%(47/59), respectively. HBsAg positive granules were in the cytoplasm, inclusion and on the karyotheca. There was a prominent positive correlation between TGF-alpha and HBsAg expression in HCC surrounding tissues (P<0.05, gamma=0.34). TGF-alpha was usually existed with HBsAg in regenerated and/or dysplastic liver cells. In the five normal liver tissues, TGF-alpha and HBsAg were not detectable in hepatocytes and bile ducts. Hepatitis B virus infection is closely related with hepatocarcinogenesis. The overexpression of TGF-alpha in the liver seems to be associated with the regeneration of hepatocytes injured by HBsAg. The continued expression of TGF-alpha might lead to dysplasia of liver cells and development of HCC. Furthermore, TGF-alpha might play a role in morphogenesis and regeneration of intrahepatic bile ducts.

Please choose payment method:






(PDF emailed within 1 workday: $29.90)

Accession: 049045398

Download citation: RISBibTeXText

Related references

Co expression of transforming growth factor alpha and hepatitis b surface antigen in the same hepatocytes of human liver tissue adjacent to hepatocellular carcinoma. Hepatology 14(4 Part 2): 109A, 1991

Transforming growth factor-alpha in human hepatocellular carcinoma and coexpression with hepatitis B surface antigen in adjacent liver. Cancer 70(5): 1049-1056, 1992

Detection of hepatitis B surface antigen and transforming growth factor alpha in oval cells of nontumorous liver in patients with hepatocellular carcinoma. Hepatology 18(4 Part 2): 185A, 1993

Expression of hepatitis B surface and core antigens and transforming growth factor-alpha in "oval cells" of the liver in patients with hepatocellular carcinoma. Journal of Medical Virology 43(3): 216-221, 1994

Expression transforming growth factor beta 1 , transforming growth factor alpha and proliferating cell nuclear antigen in 37 cases of hepatocellular carcinoma , including 10 of the fibrolamellar variety and 3 hepatoblastomas. Pathology Research and Practice 191(7-8): 637, 1995

Synergy between transforming growth factor alpha and hepatitis B virus surface antigen in hepatocellular proliferation and carcinogenesis. Cancer Research 57(16): 3606-3611, 1997

Differential expression of transforming growth factor alpha and insulin-like growth factor II in chronic active hepatitis B, cirrhosis and hepatocellular carcinoma. Journal of Hepatology 22(3): 286-294, 1995

Growth kinetic study of human hepatocellular carcinoma using proliferating cell nuclear antigen and Lewis Y antigen: their correlation with transforming growth factor-alpha and beta 1. Oncology 54(3): 245-251, 1997

Semiquantitative analysis of transforming growth factor alpha mRNA in liver tissues of patients with chronic viral hepatitis and hepatocellular carcinoma. Gastroenterology 112(4 Suppl): A1245, 1997

Significance of hepatitis B virus surface antigen, hepatitis C virus expression in hepatocellular carcinoma and pericarcinomatous tissues. World Journal of Gastroenterology 13(12): 1870-1874, 2007

Significance of the overexpression of transforming growth factor alpha, transforming growth factor beta1 and vascular endothelial growth factor in patients with hepatocellular carcinoma. Hepatology 30(4 Part 2): 680A, 1999

Expression of transforming growth factor alpha tgf alpha in human hepatocellular carcinoma hcc. Proceedings of the American Association for Cancer Research Annual Meeting 32: 51, 1991

Expression of transforming growth factor alpha in human hepatocellular carcinoma. Liver 13(3): 151-155, 1993

Expression of transforming growth factor-alpha mRNA in livers of patients with chronic viral hepatitis and hepatocellular carcinoma. Cancer 89(5): 977-982, 2000

Expression of transforming growth factor alpha and epidermal growth factor receptor in human hepatocellular carcinoma. Liver 17(4): 177-182, 1997