+ Site Statistics
References:
54,258,434
Abstracts:
29,560,870
PMIDs:
28,072,757
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Folate concentrations and folic acid supplementation among women in their first trimester of pregnancy in a rural area with a high prevalence of neural tube defects in Shanxi, China



Folate concentrations and folic acid supplementation among women in their first trimester of pregnancy in a rural area with a high prevalence of neural tube defects in Shanxi, China



Birth Defects Research. Part A, Clinical and Molecular Teratology 76(6): 461-466



Although an information campaign concerning periconceptional folic acid supplementation was launched in 1998 in Shanxi Province, China, the prevalence of neural tube defects in rural areas was reported as high as 140 per 10,000 births in 2002. The blood folate concentrations and the practice of folic acid supplementation among pregnant women in rural areas of the province are described. A total of 483 pregnant women (mean gestation, 8.1 weeks) in a rural area of Shanxi were interviewed. Nonfasting blood samples and information on folic acid supplementation were collected. Folate concentrations in plasma and erythrocytes were determined by a microbiological assay. The mean concentrations of plasma and erythrocyte folate for pregnant women was 10.4 nmol/liter and 375.8 nmol/liter, respectively. Deficiencies of plasma and erythrocyte folate were observed in 20.9% and 47.6% of women, respectively. Seasonal variations were noted in the prevalence of folate deficiency, with significantly lower plasma folate concentrations in spring and summer and lower erythrocyte folate concentrations in seasons other than summer. Among pregnant women, <10% reported having taken or currently taking folic acid, and virtually no women (0.6%) took folic acid as recommended. Women in rural areas had low plasma and erythrocyte folate levels, and folate deficiency was highly prevalent in the area. Few women followed the recommendations regarding folic acid supplementation, and the information campaign in Shanxi was unsuccessful. These findings suggest the urgent need for combined strategies in rural areas to fortify grain with folic acid and promote folic acid supplements for childbearing-age women.

Please choose payment method:






(PDF emailed within 0-6 h: $19.90)

Accession: 049096856

Download citation: RISBibTeXText

PMID: 16933216

DOI: 10.1002/bdra.20271


Related references

Awareness and use of folic acid, and blood folate concentrations among pregnant women in northern China--an area with a high prevalence of neural tube defects. Reproductive Toxicology 22(3): 431-436, 2006

Plasma and red blood cell folate levels among women in their first trimester of pregnancy from rural areas with high or low prevalence of neural tube defects, China. Zhonghua Liu Xing Bing Xue Za Zhi 27(8): 659-663, 2006

Plasma folate levels in early to mid pregnancy after a nation-wide folic acid supplementation program in areas with high and low prevalence of neural tube defects in China. Birth Defects Research. Part A, Clinical and Molecular Teratology 103(6): 501-508, 2016

Periconceptional folic acid and the gender of offspring with neural tube defects in a high-prevalence area of China Sino-US NTD project. Teratology 63(6): 275, 2001

Low folic acid supplement intake rate among women in northern China with a high-prevalence of neural tube defects, 2008. Preventive Medicine 51(3-4): 338-339, 2011

Folic acid awareness and intake among women in areas with high prevalence of neural tube defects in China: a cross-sectional study. Public Health Nutrition 14(7): 1142-1147, 2012

Extremely high prevalence of neural tube defects in a 4-county area in Shanxi Province, China. Birth Defects Research. Part A, Clinical and Molecular Teratology 76(4): 237-240, 2006

Multivitamin/folic acid supplementation in early pregnancy reduces the prevalence of neural tube defects. JAMA 262(20): 2847-2852, 1989

Multivitamin folic acid supplementation in the earliest weeks of pregnancy reduces the prevalence of neural tube defects. American Journal of Human Genetics 45(4 SUPPL): A245, 1989

Folic acid fortified milk increases blood folate to concentrations associated with a very low risk of neural tube defects in Singaporean women of childbearing age. Asia Pacific Journal of Clinical Nutrition 25(1): 62-70, 2016

Prevention of neural tube defects: prevalence of folic acid supplementation during pregnancy and associated factors in Pelotas, Rio Grande do Sul State, Brazil. Cadernos de Saude Publica 23(11): 2716-2726, 2007

Folate deficiency and folic acid supplementation: the prevention of neural-tube defects and congenital heart defects. Nutrients 5(11): 4760-4775, 2014

Folic acid prevents neural tube defects in high prevalence area. Indian Pediatrics 34(6): 561-562, 1997

Kinetics of folate turnover in pregnant women (second trimester) and nonpregnant controls during folic acid supplementation: stable-isotopic labeling of plasma folate, urinary folate and folate catabolites shows subtle effects of pregnancy on turnover of folate pools. Journal of Nutrition 131(7): 1928-1937, 2001

Formate Supplementation May Prevent Some Neural Tube Defects that Prove Resistant to Folic Acid: Supplementation with formate rescued normal neural tube closure in more than three quarters of the embryos of novel folic acid-resistant neural tube defect mouse models. American Journal of Medical Genetics. Part A 176(8): 1697-1698, 2018