+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Gastric hepatoid adenocarcinoma and familial investigation: does it always produce alpha-fetoprotein?



Gastric hepatoid adenocarcinoma and familial investigation: does it always produce alpha-fetoprotein?



European Journal of Gastroenterology and Hepatology 15(11): 1241-1244



We present the case of a 68-year-old Caucasian man with gastric hepatoid adenocarcinoma without increased levels of alpha-fetoprotein (AFP) in the serum. The patient had a strong history of gastric cancer in his family, affecting seven members, including a brother and a sister. The patient underwent subtotal gastrectomy, but 4 months later presented hepatic metastases, and 6 months after the initial diagnosis he succumbed to the disease. Immunohistochemical tests showed that the tumour was positive for AFP, hepatocyte paraffin 1, and neuron-specific enolase, but negative for synaptophysin and chromogranin. Previously reported cases of hepatoid gastric tumours showed that they produce large amounts of AFP and that they have a poor prognosis.

Please choose payment method:






(PDF emailed within 1 workday: $29.90)

Accession: 049136370

Download citation: RISBibTeXText

PMID: 14560160


Related references

Alpha fetoprotein producing gastric hepatoid adenocarcinoma. Jpma. Journal of the Pakistan Medical Association 56(6): 292-294, 2006

Alpha-fetoprotein-producing hepatoid gastric adenocarcinoma in a child presenting with spontaneous gastric perforation. Turkish Journal of Pediatrics 56(1): 88-91, 2015

Alpha-fetoprotein-producing poorly differentiated gastric adenocarcinoma: hepatoid carcinoma?. Gastroenterologie Clinique et Biologique 28(1): 77-79, 2004

Gastric hepatoid adenocarcinoma and familial investigation. European Journal of Gastroenterology & Hepatology 15(11): 1241-1244, 2003

A case of alpha-fetoprotein-producing adenocarcinoma of the endometrium with a hepatoid component as a potential source for alpha-fetoprotein in a postmenopausal woman. International Journal of Gynecological Cancer 16(3): 1442-1445, 2006

Different characteristics of hepatoid and non-hepatoid alpha-fetoprotein-producing gastric carcinomas: an experimental study using xenografted tumors. International Journal of Cancer 58(3): 430-435, 1994

Evidence for hepatocellular differentiation in alpha-fetoprotein-negative gastric adenocarcinoma with hepatoid morphology: a study with in situ hybridisation for albumin mRNA. Pathology 37(3): 211-215, 2005

Gastric composite tumor of alpha fetoprotein-producing carcinoma/hepatoid adenocarcinoma and endocrine carcinoma with reference to cellular phenotypes. Pathology Research International 2012: 201375, 2012

An alpha-fetoprotein-producing hepatoid adenocarcinoma of the endometrium. Gynecologic Oncology 83(2): 418-421, 2001

Hepatoid adenocarcinoma of the gallbladder with production of alpha-fetoprotein. Journal of the Korean Surgical Society 80(6): 440-444, 2011

Alpha-fetoprotein production by a hepatoid adenocarcinoma of the uterus. Journal of Clinical Pathology 49(5): 420-422, 1996

Hepatoid adenocarcinoma of the endometrium associated with alpha-fetoprotein production. International Journal of Gynecological Pathology 15(3): 266-269, 1996

Triple composite tumor of stomach: a rare combination of alpha fetoprotein positive hepatoid adenocarcinoma, tubular adenocarcinoma and large cell neuroendocrine carcinoma. Indian Journal of Pathology and Microbiology 57(1): 98, 2015

Α-fetoprotein producing hepatoid gastric adenocarcinoma with neuroendocrine differentiation: A case report. Medicine 97(37): E12359, 2018

Hepatoid adenocarcinoma of the lung with negative alpha-fetoprotein: a case report. Zhonghua Zhong Liu Za Zhi 40(12): 910-911, 2018