EurekaMag.com logo
+ Site Statistics
References:
47,893,527
Abstracts:
28,296,643
+ Search Articles
+ Subscribe to Site Feeds
EurekaMag Most Shared ContentMost Shared
EurekaMag PDF Full Text ContentPDF Full Text
+ PDF Full Text
Request PDF Full TextRequest PDF Full Text
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter
Follow on Google+Follow on Google+
Follow on LinkedInFollow on LinkedIn

+ Translate

Genetic comparison of large fragment of the 5'untranslated region among foot-and-mouth disease viruses with special reference to serotype Asia1


, : Genetic comparison of large fragment of the 5'untranslated region among foot-and-mouth disease viruses with special reference to serotype Asia1. Archives of Virology 150(11): 2217-2239

Foot-and-mouth disease (FMD), the most economically important disease of cloven-hoofed animals, is endemic in India. Sequence analysis revealed that phylogenetic grouping of type Asia1 field isolates on the basis of the large fragment of the 5'untranslated region (5'LF-UTR) was quite similar to that based on the sequences of the capsid-coding (VP1) region of the same viruses. The existence of two distinct lineages of type Asia1 suggested by the study on the VP1 region was further supported by the detection of a difference in length and predicted secondary structure of the 5'LF-UTR between the two lineages. Sequence variability between the isolates of the two lineages was also observed within the different domains of the internal ribosome entry site (IRES) around conserved motifs like the GNRA,- RAAA,- and the polypyrimidine tract. Certain group and lineage-specific signature nucleotides pertaining to FMDV type Asia1 in the 5'LF-UTR have been identified. The present study shows that the 5'LF-UTR of FMDV serotype Asia1 field isolates are variable in relation to the length and probable secondary structure of the IRES.


Accession: 049149305

PMID: 15968474

DOI: 10.1007/s00705-005-0576-z

Submit PDF Full Text: Here


Submit PDF Full Text

No spam - Every submission is manually reviewed

Due to poor quality, we do not accept files from Researchgate

Submitted PDF Full Texts will always be free for everyone
(We only charge for PDFs that we need to acquire)

Select a PDF file:
Close
Close

Related references

Biswas, S.; Sanyal, A.; Hemadri, D.; Tosh, C.; Mohapatra, J.K.; Kumar, R.M.; Bandyopadhyay, S.K., 2005: Genetic comparison of large fragment of the 5' untranslated region among foot-and-mouth disease viruses with special reference to serotype Asia1. Foot-and-mouth disease (FMD), the most economically important disease of cloven-hoofed animals, is endemic in India. Sequence analysis revealed that phylogenetic grouping of type Asia1 field isolates on the basis of the large fragment of the 5&apo...

Mohapatra, J.K.; Sahu, A.; Barik, S.K.; Sanyal, A.; Pattnaik, B., 2009: Comparative analysis of the large fragment of the 5' untranslated region (LF-5' UTR) of serotype A foot-and-mouth disease virus field isolates from India. India is endemic for foot-and-mouth disease (FMD) and in recent years a unique group within serotype A, carrying a codon deletion at an antigenically critical site in capsid protein VP3 has emerged (VP3(59)-deletion group). This tempted us to anal...

Escarmís, C.; Dopazo, J.; Dávila, M.; Palma, E.L.; Domingo, E., 1995: Large deletions in the 5'-untranslated region of foot-and-mouth disease virus of serotype C. Nucleotide sequences of the 5'-untranslated region (5'-UTR), at the 3'-side of the poly C tract, have been compared for 21 isolates of foot-and-mouth disease virus (FMDV) of serotype C from Europe, South America and The Philippines....

Escarmis, C.; Dopazo, J.; Davila, M.; Palma, E.L.; Domingo, E., 1995: Large deletions in the 5'-untranslated region of foot-and-mouth disease virus of serotype C. Nucleotide sequences of the 5'-untranslated region (5'-UTR), at the 3'-side of the poly C tract, have been compared for 21 isolates of foot-and-mouth disease virus (FMDV) of serotype C from Europe, South America and The Philippines....

Stram, Y.; Laor, O.; Molad, T.; Chai, D.; Moore, D.; Yadin, H.; Becker, Y., 1994: Nucleotide sequence of the P1 region of serotype Asia1 foot-and-mouth disease virus. Differences in the amino acid sequence of foot-and-mouth disease virus (FMDV) virion proteins (VP) among the various FMDV serotypes, particularly in the VP1 polypeptide, are the basis for antigenic diversity of this virus group. This phenomenon pr...

Stram, Y.; Laor, O.; Moland, T.; Chai, D.; Moore, D.; Yadin, H.; Becker, Y., 1994: Nucleotide sequence of the P1 region of serotype Asia1 foot-and-mouth disease virus. Differences in the amino acid sequence of foot-and-mouth disease virus (FMDV) virion proteins (VP) among the various FMDV serotypes, particularly in the VP1 polypeptide, are the basis for antigenic diversity of this virus group. This phenomenon pr...

Kumar, R.M.noj; Sanyal, A.; Hemadri, D.; Tosh, C.; Mohapatra, J.K.; Bandyopadhyay, S.K., 2004: Characterization of foot-and-mouth disease serotype Asia1 viruses grown in the presence of polyclonal antisera in serology and nucleotide sequence analysis. Foot-and-mouth disease viruses (FMDV) have a high rate of mutation and spontaneous mutants can be readily. isolated in the laboratory. In this study, plaque purified FMDV Asial vaccine strains (IND 63/72 and IND 491/97) were passaged in-vitro in B...

Subramaniam, S.; Mohapatra, J.K.; Sharma, G.K.; Das, B.; Dash, B.B.; Sanyal, A.; Pattnaik, B., 2014: Phylogeny and genetic diversity of foot and mouth disease virus serotype Asia1 in India during 1964-2012. Foot and mouth disease virus (FMDV) serotype Asia1 was first identified in India in 1951 and since then causing significant proportion of FMD outbreaks in the country. In this paper genetic analysis of 219 isolates from India collected over a peri...

Subramaniam, S.; Mohapatra, J.K.; Das, B.; Sharma, G.K.; Biswal, J.K.; Mahajan, S.; Misri, J.; Dash, B.B.; Pattnaik, B., 2015: Capsid coding region diversity of re-emerging lineage C foot-and-mouth disease virus serotype Asia1 from India. Foot-and-mouth disease virus (FMDV) serotype Asia1 was first reported in India in 1951, where three major genetic lineages (B, C and D) of this serotype have been described until now. In this study, the capsid protein coding region of serotype Asi...

Mohapatra, J.K.; Sanyal, A.; Hemadri, D.; Tosh, C.; Sabarinath, G.P.; Manoj Kumar, R.; Venkataramanan, R.; Bandyopadhyay, S.K., 2004: Sequence variability in the structural protein-encoding region of foot-and-mouth disease virus serotype Asia1 field isolates. A total of 30 field isolates of foot-and-mouth disease virus (FMDV) serotype Asia1 belonging to two different lineages and five isolates belonging to a divergent group as delineated earlier in 1D (encoding VP1 protein) gene-based phylogeny were se...