+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Herpesvirus DNA (Epstein-Barr virus, herpes simplex virus, cytomegalovirus) in circulating monocytes of patients with coronary artery disease



Herpesvirus DNA (Epstein-Barr virus, herpes simplex virus, cytomegalovirus) in circulating monocytes of patients with coronary artery disease



Acta Cardiologica 60(6): 605-610



The underlying mechanism of the chronic inflammatory process in atherosclerosis is still unknown. As a possible trigger, several studies in recent years have suggested that different viruses and bacteria are associated with atherosclerotic diseases. We applied polymerase chain reaction to analyse whether Epstein-Barr virus (EBV), herpes simplex virus (HSV), and cytomegalovirus (CMV) DNA could be detected in CD14 + cells from 184 patients with angiographically documented coronary artery disease (CAD) (74 patients with stable angina (SAP), 51 patients with unstable angina (UAP), and 59 patients with myocardial infarction (MI)) and from 52 healthy controls. In two patients (one patient with SAP, one patient with UAP) with CAD and one healthy control, DNA from CMV was found (p = 0.469). HSV DNA was detected in one patient (SAP) but not in any controls (p = 0.644). EBV DNA was found in nine patients (three patients with SAP, one patient with UAP, five patients with MI), and two controls (p = 0.752). Our data do not support the hypothesis that herpesvirus-infected monocytes are related to the incidence of human coronary atherosclerosis.

Please choose payment method:






(PDF emailed within 1 workday: $29.90)

Accession: 049215146

Download citation: RISBibTeXText

PMID: 16385921


Related references

Rapid quantitative PCR assays for the simultaneous detection of herpes simplex virus, varicella zoster virus, cytomegalovirus, Epstein-Barr virus, and human herpesvirus 6 DNA in blood and other clinical specimens. Journal of Medical Virology 80(3): 467-477, 2008

Relation of depressive symptoms to C-reactive protein and pathogen burden (cytomegalovirus, herpes simplex virus, Epstein-Barr virus) in patients with earlier acute coronary syndromes. American Journal of Cardiology 95(3): 317-321, 2005

Rapid and simultaneous detection of 6 types of human herpes virus (herpes simplex virus, varicella-zoster virus, Epstein-Barr virus, cytomegalovirus, human herpes virus 6A/B, and human herpes virus 7) by multiplex PCR assay. Biomedical Research 30(5): 279-285, 2009

Rapid quantitative PCR assays for simultaneous detection of herpes simplex, varicella zoster virus, cytomegalovirus, Epstein-Barr virus, and human herpesvirus 6 DNA in blood and other clinical specimens (vol 80, pg 467, 2008). 2007

Lymphoproliferative response to herpes simplex virus type 1, cytomegalovirus, Epstein-Barr virus, varicella zoster virus, human herpes virus 6, 7, and 8 antigen stimulation in pediatric allogeneic stem cell transplant recipients. Pediatric Transplantation 14(6): 761-769, 2010

Antibodies to Epstein-Barr virus, herpes simplex type 1, cytomegalovirus and measles virus in psychiatric patients. Archives of Virology 67(4): 333-339, 1981

Herpes simplex virus, cytomegalovirus and Epstein-Barr virus antibody titres in sera from schizophrenic patients. Psychological Medicine 16(4): 757-763, 1986

Prevalence of antibodies against herpes simplex virus, Epstein-Barr virus and cytomegalovirus in a group of patients after hemodialysis. Revista Cubana de Medicina Tropical 51(3): 172-176, 2000

Persistence reactivation and cell transformation by human herpesviruses herpes simplex virus type 1 herpes simplex virus type 2 cytomegalovirus varicella zoster epstein barr virus. Canadian Journal of Microbiology 25(3): 254-260, 1979

Herpes simplex virus type-2, cytomegalovirus and Epstein-Barr virus infection in acute non A and E hepatitis Thai patients. Asian Pacific Journal of Allergy & Immunology 15(3): 147-151, 1997

Herpes simplex virus type-2, cytomegalovirus and Epstein-Barr virus infection in acute non A to E hepatitis Thai patients. Asian Pacific Journal of Allergy and Immunology 15(3): 147-151, 1997

A molecular hybridization study for the presence of Herpes simplex, cytomegalovirus and Epstein-Barr virus in brain and blood of Alzheimer's disease patients. Archives of Gerontology and Geriatrics 15(1): 35-41, 1992

High seroprevalence of cytomegalovirus, herpes simplex type 1 virus and Epstein Barr virus infection among human immunodeficiency virus-infected adults. Revista Medica de Chile 138(7): 809-814, 2010

Herpes simplex virus cytomegalovirus varicella herpes zoster and epstein barr virus. KNIGHT, VERNON (ED ) VIRAL AND MYCOPLASMAL INFECTIONS OF THE RESPIRATORY TRACT XI+250P ILLUS LEA and FEBIGER: PHILADELPHIA, PA , U S A 167-199, 1973

Behaviour of IgG antibody avidity for the antigen and of IgA antibody in active cytomegalovirus, Epstein-Barr virus, herpes simplex virus and human herpes virus 6 infections. Adaptation of a commercial test. Journal of Infection 35(1): 25-30, 1997