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A priming dose protects against gold nanoparticles-induced proinflammatory cytokines mRNA expression in mice



A priming dose protects against gold nanoparticles-induced proinflammatory cytokines mRNA expression in mice



Nanomedicine 13(3): 313-323



To study the effect of priming doses of gold nanoparticles (GNPs) on proinflammatory cytokines in different organs of mice. Mice were injected with a single or two doses (priming group) of GNPs (5, 20 and 50 nm) and sacrificed after 1 or 7 days. The mRNA expressions of IL-1β, IL-6 and TNF-α were determined in liver, kidney and spleen. A single injection of 5 nm GNPs significantly increased the mRNA expressions of IL-1β and IL-6 in liver, which were normalized on day 7. In spleen, the GNPs of all sizes significantly increased IL-1β and IL-6 mRNA expressions on day 1 that persisted on day 7. The priming dose of GNPs protected the animals against the acute phase induction of IL-1β and IL-6 expressions in liver and spleen. Primed animals showed protection against GNP-induced acute immune activation suggesting the importance of the priming dose in nanomedicine.

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Accession: 049248740

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PMID: 29231780

DOI: 10.2217/nnm-2017-0332


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