EurekaMag
+ Translate
+ Most Popular
Gaucher's disease;thirty-two years experience at Siriraj Hospital
A study of Macrobathra Meyrick from China (Lepidoptera, Cosmopterigidae)
First occurrence in ores of tetragonal chalcocite
Effects of trace element nutrition on sleep patterns in adult women
N.Z. range management guidelines. 2. Design of grazing management systems for tussock country
A case of lipoma of the esophagus
A revision of world Acanthosomatidae (Heteroptera: Pentatomidae): keys to and descriptions of subfamilies, tribes and genera, with designation of types
Life history of the coronate scyphozoan Linuche unguiculata (Swartz, 1788)
Perceptual restoration of obliterated sounds
Mutagenicity studies on two chromium(III) coordination compounds
The formation of the skeleton. I. Growth of a long bone. 1st appearance of a center of calcification
Leucopenia and abnormal liver function in travellers on malaria chemoprophylaxis
The joint commission: four key root causes loom large in sentinel event data
Treatment of vitiligo with topical 15% lactic acid solution in combination with ultra violet-A
Behaviour of dairy cows within three hours after feed supply: I. Influence of housing type and time elapsing after feed supply
Observations of the propagation velocity and formation mechanism of burst fractures caused by gunshot
Management and control of patients with type 2 diabetes mellitus in Lebanon: results from the International Diabetes Management Practices Study (IDMPS)
The diet composition and nutritional knowledge of patients with anorexia nervosa
Physoporella croatica Herak, 1958 of the Slovak karst Anisian (Slovakia, the West Carpathians Mts.)
Bright lights, big noise. How effective are vehicle warning systems?
Ein Plesiosaurier-Rest mit Magensteinen aus mittlerem Lias von Quedlinburg
Incidence of Chlamydia trachomatis in patients with sterility
Monster soup: the microscope and Victorian fantasy
Preliminary tests with residual sprays against poultry lice
Duration of the life of plants in phylogeny

IgE cross reactivity between reindeer and bovine milk beta-lactoglobulins in cow's milk allergic patients


IgE cross reactivity between reindeer and bovine milk beta-lactoglobulins in cow's milk allergic patients



Journal of Investigational Allergology and Clinical Immunology 16(5): 296-302



ISSN/ISBN: 1018-9068

PMID: 17039668

Allergic reactions to cow's milk are common in small children. One of the main protein allergens found in cow's milk is beta-lactoglobulin (beta-Lg). Reindeer and bovine milk both contain related beta-Lg proteins, but the allergenicity of reindeer beta-Lg has not previously been studied. The purpose of this study was to analyze the immunological cross-reactivity of IgE antibodies from children with cow's milk allergy to reindeer and bovine beta-Lg. Sera from 17 children and a serum pool of 4 patients with elevated cow's milk-specific IgE were investigated. Beta-Lg from bovine and reindeer milk was isolated in native form and an enzyme-linked immunosorbent inhibition assay was developed. Bovine beta-Lg was used as a capturing antigen and the inhibiting effects of reindeer and bovine beta-Lg on the IgE binding were measured. Cross-reactivity patterns of bovine milk beta-Lg specific IgE to reindeer beta-Lg varied among patients. In general, reindeer beta-Lg showed significantly lower inhibition (mean 43%) of IgE binding to the capturing antigen than did bovine beta-Lg (mean 89%). In some patients, even high concentrations of reindeer beta-Lg only partly eliminated the IgE binding to bovine beta-Lg. The partial cross-reactivity of human anti-bovine IgE with reindeer beta-Lg suggests that it lacks important bovine epitopes and those that are recognized are only weakly bound.

Please choose payment method:






(PDF emailed within 1 workday: $29.90)

Accession: 049281826

Download citation: RISBibTeXText

Related references

Electrophoretic study of genetic variants of milk proteins in White-Russian livestock. beta -lactoglobulins and alpha -, beta -, and kappa -caseins of cow's milk. I. Vesti Akademii Navuk Belaruskai SSR, Seryya Sel' skagaspadarchykh Navuk 1: 110-116, 142-143, 1971

Addition of cow milk to buffalo milk. 2. Analysis by determining the C-terminal amino acids of the beta-lactoglobulins of the two milks. Annali della Facolta' di scienze agrarie della Universita' degli studi di Napoli Portici Serie quartat Semester 13(1): 133-137, 1979

Comparison of the beta-lactoglobulins of buffalo's milk and cow's milk. Nature 190: 343-344, 1961

Microplate screening assay for binding of ligands to bovine or reindeer beta-lactoglobulins. Journal of Biochemical and Biophysical Methods 68(2): 75-85, 2006

Immunological IgE cross-reactions of bovine and human alpha-lactalbumins in cow's milk allergic patients. Food and Agricultural Immunology 11(2): 179-189, 1999

Immunological IgE Cross-Reactions of Bovine and Human -Lactalbumins in Cow's Milk Allergic Patients. Food and Agricultural Immunology 11(2): 179-189, 1999

Cross-over clinical trial for evaluating the safety of camel's milk intake in patients who are allergic to cow's milk protein. Allergologia et Immunopathologia 46(2): 149-154, 2018

Electrophoretic studies on beta -lactoglobulin of buffalo's milk. Comparison of beta -lactoglobulins of cow's and buffalo's milk. Bull. natn. Inst. Sci. India. 29: 289-300, 1965

Specificity of IgE antibodies from patients allergic to goat's milk and tolerant to cow's milk determined with plasmin-derived peptides of bovine and caprine β-caseins. Molecular Nutrition and Food Research 56(10): 1532-1540, 2012

Detection and quantification of bovine, ovine and caprine milk percentages in protected denomination of origin cheeses by reversed-phase high-performance liquid chromatography of beta-lactoglobulins. Journal of Chromatography A 1015(1-2): 111-118, 2003

IgE cross-reactivity with caseins from different species in humans allergic to cow's milk. Food and Agricultural Immunology 11(1): 101-111, 1999

The whey proteins of bovine milk: B-Lactoglobulins A and B. Biochem Biophys Acta 147(1): 123-134, 1967

Occurrence of different beta-lactoglobulins in cow's milk. Nature 176(4474): 218-219, 1955

The milk production of reindeer cows and the share of milk in the growth of reindeer calves. Maataloust. Aikakausk 43(1): 1-10, 1971

An evaluation with piglets of bovine milk, hydrolyzed bovine milk, and isolated soybean proteins included in infant milk formulas. II. Stomach-emptying rate and the postprandial change in gastric pH and milk-clotting enzyme activity. Journal of Pediatric Gastroenterology and Nutrition 12(2): 253-259, 1991