EurekaMag.com logo
+ Site Statistics
References:
53,517,315
Abstracts:
29,339,501
+ Search Articles
+ Subscribe to Site Feeds
EurekaMag Most Shared ContentMost Shared
EurekaMag PDF Full Text ContentPDF Full Text
+ PDF Full Text
Request PDF Full TextRequest PDF Full Text
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter
Follow on Google+Follow on Google+
Follow on LinkedInFollow on LinkedIn

+ Translate

Immediate control of life-threatening digoxin intoxication in a child by use of digoxin-specific antibody fragments (Fab)



Immediate control of life-threatening digoxin intoxication in a child by use of digoxin-specific antibody fragments (Fab)



Paediatric Anaesthesia 13(6): 541-549



Digoxin-immune antibody fragments (Fab) for treatment of digitalis intoxication was introduced in 1976. Many reports have been published concerning this therapy for children, but few have focused on its immediate reversal of cardiac as well as extracardiac life-threatening manifestations of digoxin toxicity. We present a case of life-threatening digitalis intoxication in a child with postoperative renal insufficiency, after a Sennings procedure for transposition of the great arteries. Digoxin administration according to the nationally recommended dosage and intervals unexpectedly resulted in serum levels in the toxic range. Severe cardiac arrhythmias, haemodynamic instability and a rapid-increasing serum potassium level resulted. This report demonstrates how administration of Fab according to the manufacturer's dosage recommendation reversed the tachyarrhythmia immediately and re-established a normal level of serum potassium within minutes.

(PDF same-day service: $19.90)

Accession: 049287956

Download citation: RISBibTeXText

PMID: 12846714

DOI: 10.1046/j.1460-9592.2003.01068.x



Related references

Treatment of life-threatening digoxin poisoning with heterologous digoxin-specific antibody fragments. Deutsche Medizinische Wochenschrift 108(38): 1441-1443, 1983

Severe digoxin intoxication in a child treated by infusion of digoxin-specific Fab-antibody-fragments. European Journal of Pediatrics 142(2): 138-140, 1984

Early digoxin-specific antibody fragments for treating patients at risk of life-threatening digoxin toxicity. Clinical Toxicology 52(9): 985-986, 2014

Treatment of life-threatening digitalis intoxication with digoxin-specific Fab antibody fragments: experience in 26 cases. New England Journal of Medicine 307(22): 1357-1362, 1982

Treatment of 150 cases of life-threatening digitalis intoxication with digoxin-specific Fab antibody fragments. Final report of a multicenter study. Circulation 81(6): 1744-1752, 1990

Treatment of life-threatening digitalis intoxication with digoxin-specific Fab antibody fragments: Smith TW, Butler VP, Haber E, et al N Engl J Med 307:13571362 Nov 1982. Annals of Emergency Medicine 12(9): 584-0, 1983

Treatment of 150 cases of life-threatening digitalis intoxication with digoxin-specific Fab antibody fragments: Antman EM, Wenger TL, Butler VP, et al Circulation 81:17441752 Jun 1990. Annals of Emergency Medicine 19(12): 1476-1477, 1990

Life threatening digoxin toxicity in children treatment with digoxin specific fab fragments. Journal of the American College of Cardiology 7(2 SUPPL A): 74A, 1986

Use of digoxin-specific antibody fragments in treatment of digoxin intoxication in hemodialysis patients. Journal of the American Society of Nephrology 5(3): 469, 1994

Treatment of digoxin intoxication in a renal failure patient with digoxin-specific antibody fragments and plasmapheresis. American Journal of Nephrology 10(6): 518-521, 1990

Digoxin-specific antibody fragments for the treatment of digoxin intoxication. Clinical Pharmacy 5(10): 826-827, 1986

Digoxin intoxication in a patient with end-stage renal disease: efficacy of digoxin-specific Fab antibody fragments and peritoneal dialysis. Therapeutic Drug Monitoring 19(5): 510-515, 1997

Treatment of life-threatening digitalis intoxication with digoxin-specific Fab antibody. Kokyu to Junkan. Respiration & Circulation 37(10): 1055-1060, 1989

No age related difference in the outcome of life threatening toxicity treated with digoxin specific antibody fragments. Journal of the American Geriatrics Society 39(8): A23, 1991

First successful curative use of digoxin-specific Fab antibody fragments in a life-threatening coconut crab (Birgus latro L.) poisoning. Toxicon 60(6): 1013-1017, 2013