+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Immunological responses against SARS-coronavirus infection in humans



Immunological responses against SARS-coronavirus infection in humans



Cellular and Molecular Immunology 1(2): 119-122



Since the outbreak of a SARS epidemic last year, significant advances have been made on our understanding of the mechanisms of interaction between the SARS coronavirus (CoV) and the immune system. Strong humoral responses have been found in most patients following SARS-CoV infection, with high titers of neutralizing Abs present in their convalescent sera. The nucleocapsid (N) and spike (S) proteins of SARS-CoV appear to be the dominant antigens recognized by serum Abs. CD4+ T cell responses against the N protein have been observed in SARS patients and an HLA-A2-restricted cytotoxic T lymphocyte epitope in the S protein has been identified. It is likely that the immune responses induced by SARS-CoV infection could also cause pathological damage to the host, especially in the case of proinflammatory cytokines. There is also evidence suggesting that SARS-CoV might be able to directly invade cells of the immune system. Our understanding on the interaction between SARS-CoV, the immune system and local tissues is essential to future diagnosis, control and treatment of this very contagious disease.

Please choose payment method:






(PDF emailed within 1 workday: $29.90)

Accession: 049293752

Download citation: RISBibTeXText

PMID: 16212898


Related references

Cellular immune responses to severe acute respiratory syndrome coronavirus (SARS-CoV) infection in senescent BALB/c mice: CD4+ T cells are important in control of SARS-CoV infection. Journal of Virology 84(3): 1289-1301, 2010

T cell responses to whole SARS coronavirus in humans. Journal of Immunology 181(8): 5490-5500, 2008

Mouse studies of SARS coronavirus-specific immune responses to recombinant replication-defective adenovirus expressing SARS coronavirus N protein. Hong Kong Medical Journal 15(Suppl. 2): 33-36, 2009

Alisporivir inhibits MERS- and SARS-coronavirus replication in cell culture, but not SARS-coronavirus infection in a mouse model. Virus Research 228: 7, 2017

Anti-SARS virus antibody responses against human SARS-associated coronavirus and animal SARS-associated coronavirus-like virus. Chinese Medical Journal 117(11): 1723-1725, 2004

Relative rates of non-pneumonic SARS coronavirus infection and SARS coronavirus pneumonia. Lancet 363(9412): 841-845, 2004

Differential sensitivities of severe acute respiratory syndrome (SARS) coronavirus spike polypeptide enzyme-linked immunosorbent assay (ELISA) and SARS coronavirus nucleocapsid protein ELISA for serodiagnosis of SARS coronavirus pneumonia. Journal of Clinical Microbiology 43(7): 3054-3058, 2005

Serological Evidence of Bat SARS-Related Coronavirus Infection in Humans, China. Virologica Sinica 33(1): 104-107, 2018

Interferon and cytokine responses to SARS-coronavirus infection. Cytokine & Growth Factor Reviews 19(2): 121-132, 2008

Immunological reaction between the peptides from S1 domain of SARS coronavirus S-protein and the serum from SARS patients. Di 1 Jun Yi Da Xue Xue Bao 24(7): 789-90 797, 2004

Human CD4(+) memory T-lymphocyte responses to SARS coronavirus infection. Virology 368(2): 317-321, 2007

Intranasal vaccination of recombinant adeno-associated virus encoding receptor-binding domain of severe acute respiratory syndrome coronavirus (SARS-CoV) spike protein induces strong mucosal immune responses and provides long-term protection against SARS-CoV infection. Journal of Immunology 180(2): 948-956, 2008

Immunodominant SARS Coronavirus Epitopes in Humans Elicited both Enhancing and Neutralizing Effects on Infection in Non-human Primates. Acs Infectious Diseases 2(5): 361-376, 2016

Memory T cell responses targeting the SARS coronavirus persist up to 11 years post-infection. Vaccine 34(17): 2008-2014, 2016

Lack of innate interferon responses during SARS coronavirus infection in a vaccination and reinfection ferret model. Plos one 7(9): E45842, 2012