+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Impact of echocardiography in the short- and long-term prognosis of patients with infective endocarditis and negative blood cultures

Impact of echocardiography in the short- and long-term prognosis of patients with infective endocarditis and negative blood cultures

Journal of Heart Valve Disease 13(6): 997-1004

Higher morbidity and mortality have been attributed to patients suffering endocarditis but with negative blood cultures. The study aim was to determine whether, in the present era of routine echocardiography, patients with negative-culture endocarditis had a worse short- and long-term outcome, and whether outcomes in patients with true negative and aborted positive blood cultures were different. When endocarditis was clinically suspected, an early (<24 h) echocardiographic examination was performed in all patients, regardless of blood culture results. In total, 151 patients diagnosed with infective endocarditis (IE) comprised the study group. Among these patients, 40 (26%) had negative blood cultures, and 28 of this subgroup (70%) had received previous antibiotic therapy. Short- and long-term features and prognosis were compared between both groups. The combined main end-point was death or need for surgical repair. Similar anatomic and clinical characteristics were present among those patients with positive and negative cultures. In addition, mortality and need for surgery with regard to short- and long-term follow up of both groups was similar. There were no significant differences between patients with true- or aborted-negative cultures in terms of short- and long-term prognosis. No differences in short- and long-term prognosis were seen among patients with IE and positive versus negative blood cultures. The prognosis was also similar between those with true negative culture versus aborted negative cultures. Early echocardiography in patients with clinically suspected IE may have changed the outcome in patients with negative cultures.

Please choose payment method:

(PDF emailed within 1 workday: $29.90)

Accession: 049296400

Download citation: RISBibTeXText

PMID: 15597596

Related references

Short and long-term prognosis of infective endocarditis. Israel Journal of Medical Sciences 32(10): 905, 1996

Multivariant analysis of the short- and very long-term prognosis of infective endocarditis. European Heart Journal 15(ABSTR Suppl. ): 216, 1994

Negative blood culture infective endocarditis in the elderly: long-term follow-up. Gerontology 53(5): 245-249, 2007

Short- and long-term prognosis of infective endocarditis in non-injection drug users: improved results over 15 years (1987-2001). Revista Espanola de Cardiologia 58(10): 1188-1196, 2005

Are blood and valve cultures predictive for long-term outcome following surgery for infective endocarditis?. European Journal of Cardio-Thoracic Surgery 17(3): 228-233, 2000

Infective endocarditis in patients with negative blood cultures: analysis of 88 cases from a one-year nationwide survey in France. Clinical Infectious Diseases 20(3): 501-506, 1995

Combined efficacy of C-reactive protein and red blood cell distribution width in prognosis of patients with culture-negative infective endocarditis. Oncotarget 8(41): 71173-71180, 2017

Short- and long-term outcomes in infective endocarditis patients: a systematic review and meta-analysis. Bmc Cardiovascular Disorders 17(1): 291, 2017

Influence of diabetes mellitus on short- and long-term outcome in patients with active infective endocarditis. Journal of Heart Valve Disease 11(5): 651-659, 2002

Infective endocarditis with negative blood cultures. British Medical Journal 2(6181): 4-4, 1979

Infective endocarditis with negative blood cultures. International Journal of Antimicrobial Agents 30(Suppl. 1): S32-S36, 2007

Is the prognosis of endocarditis with negative blood cultures different from that of endocarditis with positive cultures?. European Heart Journal 17(ABSTR Suppl. ): 254, 1996

Clinical impact of transesophageal echocardiography in the diagnosis and management of infective endocarditis significance of a negative finding. Journal of the American College of Cardiology 19(3 Suppl. A): 237A, 1992

The long term prognosis of infective endocarditis. European Heart Journal 16 Suppl B: 48-53, 1995

Negative blood cultures in infective endocarditis: a review. Southern Medical Journal 69(11): 1420-1424, 1976