EurekaMag
+ Translate
+ Most Popular
Cunninghamia lanceolata plantations in China
Mammalian lairs in paleo ecological studies and palynology
Studies on technological possibilities in utilization of anhydrous milk fat for production of recombined butter-like products
Should right-sided fibroelastomas be operated upon?
Large esophageal lipoma
Apoptosis in the mammalian thymus during normal histogenesis and under various in vitro and in vivo experimental conditions
Poissons characoides nouveaux ou non signales de l'Ilha do Bananal, Bresil
Desensitizing efficacy of Colgate Sensitive Maximum Strength and Fresh Mint Sensodyne dentifrices
Administration of fluid by subcutaneous infusion: revival of a forgotten method
Tundra mosquito control - an impossible dream?
Schizophrenia for primary care providers: how to contribute to the care of a vulnerable patient population
Geochemical pattern analysis; method of describing the Southeastern limestone regional aquifer system
Incidence of low birth weights in a hospital of Mexico City
Tabanidae
Graded management intensity of grassland systems for enhancing floristic diversity
Microbiology and biochemistry of cheese and fermented milk
The ember tetra: a new pygmy characid tetra from the Rio das Mortes, Brazil, Hyphessobrycon amandae sp. n. (Pisces, Characoidei)
Risk factors of contrast-induced nephropathy in patients after coronary artery intervention
Renovation of onsite domestic wastewater in a poorly drained soil
Observations of the propagation velocity and formation mechanism of burst fractures caused by gunshot
Systolic blood pressure in a population of infants in the first year of life: the Brompton study
Haematological studies in rats fed with metanil yellow
Studies on pasteurellosis. I. A new species of Pasteurella encountered in chronic fowl cholera
Dormancy breaking and germination of Acacia salicina Lindl. seeds
therapy of lupus nephritis. a two-year prospective study

Improvement of impaired microcirculation and tissue oxygenation by hemodilution with hydroxyethyl starch plus cell-free hemoglobin in acute porcine pancreatitis


Improvement of impaired microcirculation and tissue oxygenation by hemodilution with hydroxyethyl starch plus cell-free hemoglobin in acute porcine pancreatitis



Pancreatology: Official Journal of the International Association of Pancreatology . 6(3): 232-239



ISSN/ISBN: 1424-3903

PMID: 16534248

DOI: 10.1159/000091962

To avoid the progression from mild edematous acute pancreatitis (AP) to the severe necrotizing form, one therapeutic option is to improve pancreatic microcirculation and tissue oxygenation. The aim of the study was to evaluate the influence of improved rheology (isovolemic hemodilution) plus enhanced oxygen supply (bovine hemoglobin HBOC-301) on pancreatic microcirculation, tissue oxygenation and survival in severe acute experimental pancreatitis. Severe AP was induced in 39 pigs (25-30 kg BW) by stimulation with intravenous administration of cerulein plus a pressure- and volume-controlled 10-min intraductal infusion of glycodeoxycholic acid. Seventy-five minutes after induction of AP, animals were randomized and hemodiluted isovolemically (PAOP constant) with either 10% hydroxyethyl starch (HES) 200,000/0.5 plus HBOC-301 (+0.6 g/dl plasmatic hemoglobin; Oxyglobin, Biopure, Cambridge, Mass., USA), or 10% HES 200,000/0.5, or Ringer's solution to a hematocrit of 15%. Hemodynamics, oxygen transport parameters, pancreatic microcirculation and tissue oxygen tension were evaluated over 6 h. Then the abdomen was closed, animals were extubated and observed for 6 days. After that, the surviving animals were sacrificed and specimens were taken from the pancreas. The histopathologic findings were scored by two blinded pathologists who quantified acinar necrosis, fat necrosis, inflammation and edema. Isovolemic hemodilution with HES plus HBOC-301 reduced mortality and preserved pancreatic microcirculation compared with Ringer's solution, but was not significantly different from hemodilution with HES alone. Only treatment with HES plus HBOC-301 normalized pancreatic tissue oxygen tension compared with IHD with HES or Ringer's solution alone. IHD with HES plus HBOC-301 as a combination of rheologic and O(2)-delivering therapy may represent a novel therapeutic option for treatment of AP.

Please choose payment method:






(PDF emailed within 0-6 h: $19.90)

Accession: 049307468

Download citation: RISBibTeXText

Related references

Effects of hydroxyethyl starch and cell-free hemoglobin on microcirculation, tissue oxygenation, and survival in severe acute porcine pancreatitis: results of a randomized experimental trial. Pancreas 43(6): 855-862, 2014

Effect of the Bovine Hemoglobin Solution (Hboc-301) with and without Isovolemic Hemodilution on Pancreatic Tissue Oxygenation, Pancreatic Microcirculation and Survival in Pigs with Severe Acute Pancreatitis. Pancreas 31(4): 449-450, 2005

Room B, 10/17/2000 2: 00 PM - 4: 00 PM (PS) Tissue Oxygenation during Acute Normovolemic Hemodilution with a Newly Designed Hydroxyethyl Starch Solution in Volunteers. Anesthesiology 93(Suppl): A-203, 2000

Improvement of impaired pancreatic microcirculation by isovolemic hemodilution may protect pancreatic morphology in acute biliary pancreatitis. Pancreas 3(5): 603, 1988

Improvement of impaired pancreatic microcirculation by isovolemic hemodilution protects pancreatic morphology in acute biliary pancreatitis. Surgery Gynecology and Obstetrics 176(2): 144-150, 1993

Hydroxyethyl starch solutions and their effect on the microcirculation and tissue oxygenation. Transfusion Alternatives in Transfusion Medicine 9(3): 164-172, 2007

Effects of different types of hydroxyethyl starch (HES) on microcirculation perfusion and tissue oxygenation in patients undergoing liver surgery. International Journal of Clinical and Experimental Medicine 7(3): 631-639, 2014

Improvement of pancreatic microcirculation during acute pancreatitis by isovolemic hemodilution with dextran 60 preliminary results. Digestion 32(3): 194, 1985

Haemodilution with dextran 40 and hydroxyethyl starch and its effect on cerebral microcirculation. Journal of Neurology 236(3): 164-167, 1989

Influence of cell-free Hb on local tissue perfusion and oxygenation in acute anemia after isovolemic hemodilution. Transfusion 41(10): 1290-1298, 2001

Hydroxyethyl starch (HES) 130/0.4 during acute normovolemic hemodilution increases tissue oxygen tension larger and faster than HES 70/0.5 or HES 200/0.5. Anesthesia and Analgesia 98(2): 559-560, 2004

Extensive isovolemic hemodilution with gelatin and hydroxyethyl starch and its effects on cerebral blood flow velocity and cutaneous microcirculation. Anaesthesist 46(11): 927-937, 1997

Volemic and coagulation effects of low molecular weight hydroxyethyl-starch and modified fluid gelatin at high dosage during acute normovolemic hemodilution and subsequent further preoperative hemodilution. Anesthesia and Analgesia 78(2 Suppl): ABSTRACT S298, 1994

Hydroxyethyl starch (HES) 130/0.4 provides larger and faster increases in tissue oxygen tension in comparison with prehemodilution values than HES 70/0.5 or HES 200/0.5 in volunteers undergoing acute normovolemic hemodilution. Anesthesia and Analgesia 96(4): 936-943, 2003

Effects of angiotensin II receptor antagonist on intestinal mucosal oxygenation during canine isovolemic hemodilution with hydroxyethyl starch. Masui. Japanese Journal of Anesthesiology 52(6): 603-610, 2003