+ Site Statistics
+ Search Articles
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ PDF Full Text
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Translate
+ Recently Requested

Incidence of renal insufficiency in cancer patients and evaluation of information available on the use of anticancer drugs in renally impaired patients

Incidence of renal insufficiency in cancer patients and evaluation of information available on the use of anticancer drugs in renally impaired patients

Medical Science Monitor 10(5): Cr209-Cr212

Chronic renal failure is a common pathology. The high frequency of this disease in the general US population has been assessed in the NHANES III study. However, the frequency of chronic renal insufficiency among cancer patients remains unclear. 316 cancer patients were in a one-month study, included regardless of their pathology, treatment (antineoplastic drugs used or programmed to be used, pretreated, or no treatment), or any other criteria. Among the patients, 287 (90.8%) had normal serum creatinine levels (<110 micromol/l), i.e. a frequency of 9.2% for renal insufficiency in our population. However, when renal function was estimated by calculating creatinine clearance using the Cockcroft and Gault formula, 33% of the patients had an estimated GFR of less than 80 ml/min. Among these, 28% had a creatinine clearance ranging form 80 to 50 ml/min and 5% had a creatinine clearance of less than 50 ml/min. Renal insufficiency is frequent in cancer patients since almost one third of the patients present renal insufficiency. Furthermore, among patients with normal serum creatinine levels, one patient out of five has asymptomatic renal insufficiency. Therefore, it is of major importance that renal function be assessed by calculation of creatinine clearance using the Cockcroft and Gault formula in every patient, even when serum creatinine is within the normal range.

(PDF emailed within 1 workday: $29.90)

Accession: 049322610

Download citation: RISBibTeXText

PMID: 15114271

Related references

Prevalence of Renal Insufficiency in cancer patients and implications for anticancer drug management: the renal insufficiency and anticancer medications (IRMA) study. Cancer 110(6): 1376-1384, 2007

Renal insufficiency and anticancer drugs in elderly cancer patients: a subgroup analysis of the IRMA study. Critical Reviews in Oncology/Hematology 70(2): 124-133, 2008

Renal insufficiency in cancer patients: Prevalence and implications on anticancer drugs management. Results of the IRMA study. Journal of Clinical Oncology 24(18_suppl): 8603-8603, 2016

Anticancer drugs management in renal insufficiency patients. Bulletin du Cancer 99(3): 323-331, 2012

Pharmacokinetics and renal excretion of desmopressin after intravenous administration to healthy subjects and renally impaired patients. British Journal of Clinical Pharmacology 58(4): 352-358, 2004

Incidence of bleeding in renally impaired patients receiving incorrectly dosed eptifibatide or bivalirudin while undergoing percutaneous coronary intervention. Annals of PharmacoTherapy 46(1): 35-41, 2012

Renal excretion and plasma levels of dihydrodigitoxin in volunteers and renally healthy and renally insufficient patients being treated with digitoxin. Erdmann, E , K Greef And J C Skou (Ed ) Cardiac Glycosides 1785-1985: Biochemistry, Pharmacology, Clinical Relevance; Boehringer Mannheim International Symposia Xvii+552p Steinkopff Verlag Darmstadt: Darmstadt, West Germany; Springer-Verlag: New York, New York, Usa Illus 269-272, 1986

Renal tolerability of iopromide and iodixanol in 562 renally impaired patients undergoing cardiac catheterisation: the DIRECT study. Eurointervention 8(7): 830-838, 2013

Systematic review on the use of systemic anticancer therapy in renal-impaired gynecological cancer patients. International Journal of Gynecological Cancer 18(5): 1152, 2007

Resistance to anticancer drugs: are we ready to use biologic information for the treatment of patients with cancer?. Therapeutic Drug Monitoring 20(5): 581-587, 1998

Incidence of renal insufficiency in cancer patients. Advances in Therapy 22(4): 357-362, 2006

Evaluation of information for renal insufficiency patients before dialysis. Nephrologie 19(3): 111-116, 1998

Renal cell cancer: incidence of hemorrhage on MR images in patients with chronic renal insufficiency. Journal of Magnetic Resonance Imaging 7(1): 157-160, 1997

High incidence of renal insufficiency in ovarian cancer patients. 2007

Impact of depression mood disorder on the adverse drug reaction incidence rate of anticancer drugs in cancer patients. Journal of International Medical Research 38(6): 2153-2159, 2011