Influence of seven absorption enhancers on nasal mucosa--assessment of toxicity
Zhao, Y.; Zhang, D.-w.; Zheng, A.-p.; Yu, S.-y.; Wu, F.-l.
Beijing da Xue Xue Bao. Yi Xue Ban 36(4): 417-420
2004
ISSN/ISBN: 1671-167X PMID: 15303139 Accession: 049350159
To study the influence of seven different absorption enhancers on nasal mucosa. By testing last time of ciliary movement, velocity of ciliary movement, ciliary structural and specific cellular changes of nasal mucosa the influence of seven different absorption enhancers on nasal mucosa. The effect on lasting time of ciliary movement was 1%SDS>1%SDC>1%Brij35>5%Tween80>0.1%EDTA>5%HP-beta-CD>1%lecithin the effect on velocity of ciliary movement 1%Brij35>1%SDC>1%SDS>0.1%EDTA>1%lecithin>5%Tween80>5%HP-beta-CD,and the effect on ciliary structural and specific cellular changes of nasal mucosa 1%SDS approximately 1%SDC approximately 1%Brij35>5%Tween80>0.1%EDTA approximately 5% HP-beta-CD approximately 1%lecithin. The three methods have good correlation.