Section 50
Chapter 49,361

Inhibitors of CTP biosynthesis potentiate the anti-human immunodeficiency virus type 1 activity of 3TC in activated peripheral blood mononuclear cells

Dereuddre-Bosquet, N.; Roy, B.éa.; Routledge, K.; Clayette, P.; Foucault, G.; Lepoivre, M.

Antiviral Research 61(1): 67-70


ISSN/ISBN: 0166-3542
PMID: 14670596
DOI: 10.1016/j.antiviral.2003.08.002
Accession: 049360116

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Unlike hydroxyurea, the CTP synthetase inhibitor acivicin and, to a lesser extent, two other inhibitors of CTP synthesis, increased the phosphorylation and anti-HIV-1 activity of 3TC in PHA-P-activated PBMC. These data suggest that to improve the antiretroviral activity of 3TC, it may be worth focusing on inhibition of CTP synthesis.

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