Inhibitors of CTP biosynthesis potentiate the anti-human immunodeficiency virus type 1 activity of 3TC in activated peripheral blood mononuclear cells
Dereuddre-Bosquet, N.; Roy, B.éa.; Routledge, K.; Clayette, P.; Foucault, G.; Lepoivre, M.
Antiviral Research 61(1): 67-70
2004
ISSN/ISBN: 0166-3542 PMID: 14670596 DOI: 10.1016/j.antiviral.2003.08.002
Accession: 049360116
Unlike hydroxyurea, the CTP synthetase inhibitor acivicin and, to a lesser extent, two other inhibitors of CTP synthesis, increased the phosphorylation and anti-HIV-1 activity of 3TC in PHA-P-activated PBMC. These data suggest that to improve the antiretroviral activity of 3TC, it may be worth focusing on inhibition of CTP synthesis.
Full Text Article emailed within 0-6 h: $19.90
Related References
Shirasaka, T.; Chokekijchai, S.; Yamada, A.; Gosselin, G.; Imbach, J.L.; Mitsuya, H. 1995: Comparative analysis of anti-human immunodeficiency virus type 1 activities of dideoxynucleoside analogs in resting and activated peripheral blood mononuclear cells Antimicrobial Agents and ChemoTherapy 39(11): 2555-2559Haffar, O.K.; Smithgall, M.D.; Popov, S.; Ulrich, P.; Bruce, A.G.; Nadler, S.G.; Cerami, A.; Bukrinsky, M.I. 1998: CNI-H0294, a nuclear importation inhibitor of the human immunodeficiency virus type 1 genome, abrogates virus replication in infected activated peripheral blood mononuclear cells Antimicrobial Agents and ChemoTherapy 42(5): 1133-1138
Haffar, O.K.; Smithgall, M.D.; Popov, S.; Ulrich, P.; Bruce, A.G.; Nadler, S.G.; Cerami, A.; Bukrinsky, M.I. 1998: Cni-H0294, a Nuclear Importation Inhibitor of the Human Immunodeficiency Virus Type 1 Genome, Abrogates Virus Replication in Infected Activated Peripheral Blood Mononuclear Cells Antimicrobial Agents and Chemotherapy 42(5): 1133-1138
Buitendijk, M.; Eszterhas, S.K.; Howell, A.L. 2014: Toll-like receptor agonists are potent inhibitors of human immunodeficiency virus-type 1 replication in peripheral blood mononuclear cells Aids Research and Human Retroviruses 30(5): 457-467
Gao, W.Y.; Mitsuya, H.; Driscoll, J.S.; Johns, D.G. 1995: Enhancement by hydroxyurea of the anti-human immunodeficiency virus type 1 potency of 2'-beta-fluoro-2',3'-dideoxyadenosine in peripheral blood mononuclear cells Biochemical Pharmacology 50(2): 274-276
Kasahara, D.; Takara, A.; Takahashi, Y.; Kodama, A.; Tanaka, R.; Ansari, A.A.; Tanaka, Y. 2013: Natural OX40L expressed on human T cell leukemia virus type-I-immortalized T cell lines interferes with infection of activated peripheral blood mononuclear cells by CCR5-utilizing human immunodeficiency virus Virology Journal 10: 338
Chu, C.K.; Schinazi, R.F.; Ahn, M.K.; Ullas, G.V.; Gu, Z.P. 1989: Structure-activity relationships of pyrimidine nucleosides as antiviral agents for human immunodeficiency virus type 1 in peripheral blood mononuclear cells Journal of Medicinal Chemistry 32(3): 612-617
Chu, C.K.; Schinazi, R.F.; Arnold, B.H.; Cannon, D.L.; Doboszewski, B.; Bhadti, V.B.; Gu, Z.P. 1988: Comparative activity of 2',3'-saturated and unsaturated pyrimidine and purine nucleosides against human immunodeficiency virus type 1 in peripheral blood mononuclear cells Biochemical Pharmacology 37(19): 3543-3548
Buonaguro, L.; Tornesello, M.L.; Gallo, R.C.; Marincola, F.M.; Lewis, G.K.; Buonaguro, F.M. 2009: Th2 polarization in peripheral blood mononuclear cells from human immunodeficiency virus (HIV)-infected subjects, as activated by HIV virus-like particles Journal of Virology 83(1): 304-313
Conge, A.M.; Reynes, J.; Atoui, N.; Huguet, M.F.; Ducos, J.; Bonardet, A.; Serre, A.; Vendrell, J.P. 1994: Spontaneous in vitro anti-human immunodeficiency virus type 1 antibody secretion by peripheral blood mononuclear cells is related to disease progression in zidovudine-treated adults Journal of Infectious Diseases 170(6): 1376-1383
Corbeau, P.; Devaux, C.; Kourilsky, F.; Chermann, J.C. 1990: An early postinfection signal mediated by monoclonal anti-beta 2 microglobulin antibody is responsible for delayed production of human immunodeficiency virus type 1 in peripheral blood mononuclear cells Journal of Virology 64(4): 1459-1464
Shixing, T.A.N.G.; Jiangqin, Z.H.A.O.; Gaddam, D.; Devadas, K.; Hewlett, I.K.; Viswanath, R.; Nyambi, P.N.; Redd, A.D.; Dastyar, A.; Spacek, L.A.; Quinn, T.C.; Xue, W.A.N.G.; Wood, O. 2011: Absence of detectable xenotropic murine leukemia virus―related virus in plasma or peripheral blood mononuclear cells of human immunodeficiency virus Type 1―infected blood donors or individuals in Africa Transfusion (Philadelphia, Pa) 51(3): 463-468
Tang, S.; Zhao, J.; Viswanath, R.; Nyambi, P.N.; Redd, A.D.; Dastyar, A.; Spacek, L.A.; Quinn, T.C.; Wang, X.; Wood, O.; Gaddam, D.; Devadas, K.; Hewlett, I.K. 2011: Absence of detectable xenotropic murine leukemia virus-related virus in plasma or peripheral blood mononuclear cells of human immunodeficiency virus type 1-infected blood donors or individuals in Africa Transfusion 51(3): 463-468
Vicenzi, E.; Turchetto, L.; Ruggieri, A.; Novati, R.; Poli, G. 1995: Thenefgene of the human immunodeficiency virus type-1 (HIV-1) enhances virus replication in human peripheral blood mononuclear cells Journal of Cancer Research and Clinical Oncology 121(1 Suppl): S37-S0
Rey, F.; BouHamdan, M.; Navarro, J.M.; Agostini, I.; Willetts, K.; Bouyac, M.; Tamalet, C.; Spire, B.; Vigne, R.; Sire, J. 1998: A role for human immunodeficiency virus type 1 Vpr during infection of peripheral blood mononuclear cells Journal of General Virology 79: 1083-1087
Akari, H.; Sakuragi, J.; Takebe, Y.; Tomonaga, K.; Kawamura, M.; Fukasawa, M.; Miura, T.; Shinjo, T.; Hayami, M. 1992: Biological characterization of human immunodeficiency virus type 1 and type 2 mutants in human peripheral blood mononuclear cells Archives of Virology 123(1-2): 157-167
Rapecki, S.; Joyce, A.; Merriman, M.; Allen, R. 1996: The immunomodulatory effects of phosphodiesterase type IV inhibitors on activated human peripheral blood mononuclear cells Immunology 89(Suppl 1): 93
Zhang, L..; Waters, C..; Poisson, L..; Estis, L..; Crumpacker, C.. 1997: The Interleukin2 Fusion Protein, Dab 389 Il2, Inhibits the Development of Infectious Virus in Human Immunodeficiency Virus Type 1Infected Human Peripheral Blood Mononuclear Cells The Journal of Infectious Diseases 175(4): 790-794
Shapiro, S.Z.; Maudru, T.; Peden, K.W. 1999: Detection of human immunodeficiency virus type 1 after infection of unstimulated peripheral blood mononuclear cells Journal of General Virology 80: 857-861
Bagasra, O.; Pomerantz, R.J. 1993: Human immunodeficiency virus type 1 replication in peripheral blood mononuclear cells in the presence of cocaine Journal of Infectious Diseases 168(5): 1157-1164