+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Interferon-gamma and neopterin in alopecia areata



Interferon-gamma and neopterin in alopecia areata



Georgian Medical News 2005(123): 53-57



Alopecia areata (AA) is a disorder primarily affecting the hair in which associated autoimmune or atopic disease is common. The aim of the study was to compare the serum levels of interferon-gamma (INF-gamma) and neopterin (NPT) in 30 patients with AA and the control group (10 blood donors). We also investigated the difference between localized form of AA (I group), extensive form of AA (II group) and patients with family history of AA (III group). Each group consisted of 10 patients. The serum levels of INF-gamma and NPT were measured using enzyme immunoassay techniques. The mean serum INF-gamma level in control was 9,7+/-3,18 pg/mL. The mean serum INF-gamma level in AA patients (n = 30) was 14,6+/-4,81 pg/mL, whereas I group (n = 10) calculates 12,37+/-4,42 pg/mL; II group (n = 10) - 17,1+/-4,87 pg/mL and III group (n = 10) - 13,57+/-4,02 pg/mL. Serum levels of INF-gamma in patients with AA were significantly higher than those in controls (p=0,0017). Significant difference was observed in serum levels of INF-gamma between patients with extensive form and control group (p=0,0008). There was no significant difference in serum levels of INF-gamma between patients with localized form and control group (p=0,17); also between III group (with family history) and control group (p=0,057). Significant difference was observed in serum levels of INF-gamma between patients with extensive and localized forms of AA (p=0,047). There was no significant difference between patients with I and III (p=0,6); also II and III groups (p=0,1). The mean serum level NPT in control was 5,3+/-2,39 nmol/L. The mean serum NPT level in AA patients was 14,06+/-11,4 nmol/L, in I group it was equal to 10,16+/-10,06 nmol/L; II group - 21,78+/-10,8 nmol/L and III group - 10,24+/-10,12 nmol/L. Serum levels of NTP in patients with AA were significantly higher than those in controls (p=0,0003). Significant difference was observed in serum levels of NPT between patients with extensive form and control group (p=0,0001). There was no significant difference in serum levels of NPT between patients with localized form and control group (p=0,15): also between III group (with family history) and control group (p=0,15). Significant difference was observed in serum levels of INF-gamma between patients with extensive and localized form AA (p=0,02) and extensive and with family history (p=0,02) There was no significant difference between patients of I and III groups (p=0,98). Authors thank the company IBL-Hamburg and its representative in Georgia IRISE Ltd. for their support in this study.

Please choose payment method:






(PDF emailed within 1 workday: $29.90)

Accession: 049376660

Download citation: RISBibTeXText

PMID: 16052058


Related references

Interferon-gamma in alopecia areata. European Journal of Dermatology 14(1): 33-36, 2004

Treatment of alopecia areata with anti-interferon-gamma antibodies. Journal of Investigative Dermatology. Symposium Proceedings 10(3): 283-284, 2005

Alopecia areata induced in young C3H/HeJ mice by interferon-gamma. Journal of Investigative Dermatology 122(3): A10, 2004

Failure to induce alopecia areata in C3H/HeJ mice with exogenous interferon gamma. Journal of Experimental Animal Science 43(4): 265-270, 2007

Interferon-gamma-deficient mice are resistant to the development of alopecia areata. British Journal of Dermatology 155(3): 515-521, 2006

Selective expression of chemokine monokine induced by interferon-gamma in alopecia areata. Journal of Investigative Dermatology 121(4): 933-935, 2003

The genetic basis of alopecia areata: HLA associations with patchy alopecia areata versus alopecia totalis and alopecia universalis. Journal of Investigative Dermatology. Symposium Proceedings 4(3): 216-219, 2000

Alopecia areata induced in C3H/HeJ mice by interferon-gamma: evidence for loss of immune privilege. Journal of Investigative Dermatology 124(1): 288-289, 2005

Response of grafts from patients with alopecia areata transplanted onto nude mice, to administration of interferon-gamma. Clinical Immunology and Immunopathology 66(2): 120-126, 1993

Serum concentrations of interferon-gamma (IFN-g) in patients with alopecia areata: correlation with clinical type and duration of the disease. Medicinski Arhiv 64(4): 212-214, 2010

Localization of gamma interferon expression to the precortical matrix and inner root sheath of hair follicles in normal controls and patients with alopecia areata. Journal of Investigative Dermatology 104(4): 653, 1995

Alopecia areata universalis and disseminated mollusca contagiosa in atopic dermatitis. Hair re-growth during treatment with interferon gamma--therapeutic effect or coincidence?. Journal der Deutschen Dermatologischen Gesellschaft 3(6): 441-444, 2005

Regulatory effect of procyanidins on the expressions of interferon-gamma, interleukin-12 and transcription factor T-bet mRNA in peripheral blood mononuclear cell of patients with alopecia areata. Zhongguo Zhong Xi Yi Jie he Za Zhi Zhongguo Zhongxiyi Jiehe Zazhi 28(10): 900-902, 2008

Alopecia areata associated with neurodermatitis; report of two cases with a discussion of the relationship of alopecia areata to nervous system dysfunction. Urologic and Cutaneous Review 52(8): 467-472, 1948

Establishing and prioritizing research questions for the treatment of alopecia areata: the Alopecia Areata Priority Setting Partnership. British Journal of Dermatology 176(5): 1316-1320, 2017