EurekaMag
+ Most Popular
Cunninghamia lanceolata plantations in China
Mammalian lairs in paleo ecological studies and palynology
Studies on technological possibilities in utilization of anhydrous milk fat for production of recombined butter-like products
Should right-sided fibroelastomas be operated upon?
Large esophageal lipoma
Apoptosis in the mammalian thymus during normal histogenesis and under various in vitro and in vivo experimental conditions
Poissons characoides nouveaux ou non signales de l'Ilha do Bananal, Bresil
Desensitizing efficacy of Colgate Sensitive Maximum Strength and Fresh Mint Sensodyne dentifrices
Administration of fluid by subcutaneous infusion: revival of a forgotten method
Tundra mosquito control - an impossible dream?
Schizophrenia for primary care providers: how to contribute to the care of a vulnerable patient population
Geochemical pattern analysis; method of describing the Southeastern limestone regional aquifer system
Incidence of low birth weights in a hospital of Mexico City
Tabanidae
Graded management intensity of grassland systems for enhancing floristic diversity
Microbiology and biochemistry of cheese and fermented milk
The ember tetra: a new pygmy characid tetra from the Rio das Mortes, Brazil, Hyphessobrycon amandae sp. n. (Pisces, Characoidei)
Risk factors of contrast-induced nephropathy in patients after coronary artery intervention
Renovation of onsite domestic wastewater in a poorly drained soil
Observations of the propagation velocity and formation mechanism of burst fractures caused by gunshot
Systolic blood pressure in a population of infants in the first year of life: the Brompton study
Haematological studies in rats fed with metanil yellow
Studies on pasteurellosis. I. A new species of Pasteurella encountered in chronic fowl cholera
Dormancy breaking and germination of Acacia salicina Lindl. seeds
therapy of lupus nephritis. a two-year prospective study

A Randomized, Double-Blind, Multicenter, Placebo-Controlled Trial of Qi-Zhi-Wei-Tong Granules on Postprandial Distress Syndrome-Predominant Functional Dyspepsia


A Randomized, Double-Blind, Multicenter, Placebo-Controlled Trial of Qi-Zhi-Wei-Tong Granules on Postprandial Distress Syndrome-Predominant Functional Dyspepsia



Chinese Medical Journal 131(13): 1549-1556



ISSN/ISBN: 0366-6999

PMID: 29941708

DOI: 10.4103/0366-6999.235118

气滞胃痛颗粒治疗功能性消化不良餐后不适综合征疗效与安全性的多中心、随机、双盲、安慰剂对照临床试验摘要背景: 功能性消化不良是一种常见的上消化道功能性疾病,目前对于其药物治疗效果仍欠满意。本文旨在评估气滞胃痛颗粒对功能性消化不良的餐后不适综合征亚型的临床疗效与安全性。 方法: 采用随机、双盲、多中心、安慰剂对照的方法观察餐后不适综合征患者197例。对所有入组患者给予1周安慰剂治疗,1周后症状积分下降不大于50%的患者将被随机分配到气滞胃痛颗粒组或安慰剂组,2组治疗疗程均为4周,治疗结束后2周再次进行随访。在第0,2,4周和治疗结束后2周观察记录两组临床症状的改善情况,并采用Zung氏焦虑/抑郁自评量表(SAS/SDS)在第0,4和治疗结束后2周评估患者心理状态。 结果: 在第2,4周和治疗结束后2周,气滞胃痛颗粒组的总有效率(38.82%,69.14%,77.65%)均高于安慰剂组(8.75%,16.25%,21.25%),差异有统计学意义(P均< 0.001);在第2,4周和治疗结束后2周,气滞胃痛颗粒组的症状积分低于安慰剂组,差异有统计学意义(P < 0.001);在第2,4周和治疗结束后2周,气滞胃痛颗粒组的单症状(餐后饱胀不适、早饱)严重程度与频率均分别低于安慰剂组,差异有统计学意义(P < 0.05);在第4周和治疗结束后2周,气滞胃痛颗粒组的SAS评分低于安慰剂组,差异有统计学意义(P < 0.001);气滞胃痛颗粒组和安慰剂组均未发现严重不良事件,不良事件出现率为3.03%与3.06%,差异无统计学意义(P > 0.05)。 结论: 气滞胃痛颗粒治疗餐后不适综合征的综合疗效显著、稳定,无明显不良反应。.

Please choose payment method:






(PDF emailed within 0-6 h: $19.90)

Accession: 049406651

Download citation: RISBibTeXText

Related references

A double-blind randomized, multicenter, placebo-controlled study of itopride in functional dyspepsia postprandial distress syndrome. Neurogastroenterology and Motility: the Official Journal of the European Gastrointestinal Motility Society 34(8): E14337, 2022

Zhizhu Kuanzhong Capsule in treating patients with functional dyspepsia postprandial distress syndrome: study protocol for a multicenter, randomized, double-blind, placebo-controlled, parallel-group clinical trial. Trials 23(1): 454, 2022

The Therapeutic Outcome of Itopride in Functional Dyspepsia Postprandial Distress Syndrome: A Double-Blind Randomized, Multicenter, Placebo-Controlled Study. Gastroenterology 154(6): S-91, 2018

Efficacy and Safety of new Prokinetic Agent Benachio Q Solution® in Patients with Postprandial Distress Syndrome Subtype in Functional Dyspepsia: a Single-center, Randomized, Double-blind, Placebo-controlled Pilot Study. Korean Journal of Gastroenterology 66(1): 17-26, 2015

Tong-xie-ning, a Chinese herbal formula, in treatment of diarrhea-predominant irritable bowel syndrome: a prospective, randomized, double-blind, placebo-controlled trial. Chinese Medical Journal Beijing 119(24): 2114-2119, 2006

Tong-xie-ning, a Chinese herbal formula, in treatment of diarrhea-predominant irritable bowel syndrome: a prospective, randomized, double-blind, placebo-controlled trial. Chinese Medical Journal 119(24): 2114-2119, 2006

Randomized clinical trial: rikkunshito in the treatment of functional dyspepsia--a multicenter, double-blind, randomized, placebo-controlled study. Neurogastroenterology and Motility: the Official Journal of the European Gastrointestinal Motility Society 26(7): 950-961, 2014

Treatment of functional dyspepsia with a herbal preparation. A double-blind, randomized, placebo-controlled, multicenter trial. Digestion 69(1): 45-52, 2004

Trimebutine Maleate Monotherapy for Functional Dyspepsia: a Multicenter, Randomized, Double-Blind Placebo Controlled Prospective Trial. Medicina 56(7), 2020

Efficacy and Safety of Orally Administered Acotiamide Extended-Release Tablets Among Functional Dyspepsia-Postprandial Distress Syndrome Patients: a Randomized, Double-Blind, Multicenter Study. Cureus 13(4): E14361, 2021

Double-blind, randomized, placebo-controlled Canadian multicenter trial of two doses of synthetic surfactant or air placebo in 224 infants weighing 500 to 749 grams with respiratory distress syndrome. Journal of Pediatrics 126(5 Part 2): S81-S89, 1995

Functional Dyspepsia Treatment Trial (FDTT): a double-blind, randomized, placebo-controlled trial of antidepressants in functional dyspepsia, evaluating symptoms, psychopathology, pathophysiology and pharmacogenetics. Contemporary Clinical Trials 33(3): 523-533, 2012

A randomized, double-blind, placebo-controlled trial of polyethylene glycol effects on fasting and postprandial rectal sensitivity and symptoms in hypersensitive constipation-predominant irritable bowel syndrome. Colorectal Disease: the Official Journal of the Association of Coloproctology of Great Britain and Ireland 12(11): 1131-1138, 2010

Liposomal prostaglandin E1 in acute respiratory distress syndrome: a placebo-controlled, randomized, double-blind, multicenter clinical trial. Critical Care Medicine 24(1): 10-15, 1996

Subpopulation Analysis Based on Background Responds to Rabeprazole Dose in Patients With Functional Dyspepsia in a Multicenter, Double-Blind, Randomized, Placebo-Controlled Clinical Trial; the Samurai Study. Gastroenterology 144(5): S-194, 2013