EurekaMag
+ Translate
+ Most Popular
Gaucher's disease;thirty-two years experience at Siriraj Hospital
A study of Macrobathra Meyrick from China (Lepidoptera, Cosmopterigidae)
First occurrence in ores of tetragonal chalcocite
Effects of trace element nutrition on sleep patterns in adult women
N.Z. range management guidelines. 2. Design of grazing management systems for tussock country
A case of lipoma of the esophagus
A revision of world Acanthosomatidae (Heteroptera: Pentatomidae): keys to and descriptions of subfamilies, tribes and genera, with designation of types
Life history of the coronate scyphozoan Linuche unguiculata (Swartz, 1788)
Perceptual restoration of obliterated sounds
Mutagenicity studies on two chromium(III) coordination compounds
The formation of the skeleton. I. Growth of a long bone. 1st appearance of a center of calcification
Leucopenia and abnormal liver function in travellers on malaria chemoprophylaxis
The joint commission: four key root causes loom large in sentinel event data
Treatment of vitiligo with topical 15% lactic acid solution in combination with ultra violet-A
Behaviour of dairy cows within three hours after feed supply: I. Influence of housing type and time elapsing after feed supply
Observations of the propagation velocity and formation mechanism of burst fractures caused by gunshot
Management and control of patients with type 2 diabetes mellitus in Lebanon: results from the International Diabetes Management Practices Study (IDMPS)
The diet composition and nutritional knowledge of patients with anorexia nervosa
Physoporella croatica Herak, 1958 of the Slovak karst Anisian (Slovakia, the West Carpathians Mts.)
Bright lights, big noise. How effective are vehicle warning systems?
Ein Plesiosaurier-Rest mit Magensteinen aus mittlerem Lias von Quedlinburg
Incidence of Chlamydia trachomatis in patients with sterility
Monster soup: the microscope and Victorian fantasy
Preliminary tests with residual sprays against poultry lice
Duration of the life of plants in phylogeny

Low width of tubular bones is associated with increased risk of fragility fracture in elderly men--the MINOS study


Low width of tubular bones is associated with increased risk of fragility fracture in elderly men--the MINOS study



Bone 38(4): 595-602



ISSN/ISBN: 8756-3282

PMID: 16249130

DOI: 10.1016/j.bone.2005.09.004

The risk of fragility fractures in elderly men is only partly explained by areal bone mineral density (aBMD) measured by dual X-ray absorptiometry (DXA). Several studies suggest the importance of bone morphology for the risk of fracture. The aim of this study was to assess the value of bone size and estimated structural parameters for the prediction of incident fractures in a large cohort of men. This study was made in 759 men aged 50-85 from the MINOS cohort. During a 90-month follow-up, 74 men sustained incident vertebral and peripheral fractures. Areal BMD was measured by DXA at femoral neck, distal radius and distal ulna. Estimates of structural bone parameters and volumetric BMD (vBMD) were derived from aBMD measured by DXA. Given the limited number of fractures, the predictive value of investigated parameters was assessed for peripheral and vertebral fractures jointly by using logistic regression. Men who sustained the fractures had, at baseline, lower aBMD (3.5-6.5%), lower bone mineral content (BMC 5.4-8.7%) and lower cortical thickness (3.5-6.9%) compared with the men without fracture. At all the three skeletal sites, aBMD, BMC, width, cortical area and thickness, cross-sectional moment of inertia (CSMI), and section modulus predicted incident fractures (O.R. = 1.28-1.92 per 1 SD decrease, P < 0.05-0.0001). Fracture risk was weakly associated with vBMD for ulna (O.R. = 1.25 per 1 SD decrease, P < 0.05) but not for femoral neck or radius. After adjustment for aBMD, bone width remained a significant predictor of fractures (O.R. = 1.37-1.48 per 1 SD decrease, P < 0.02-0.01). Men with osteopenia (BMD T score < -1) and low bone width (T score < -1) had the fracture incidence similar to that observed in men with BMD T score < -2. Bone width and aBMD of the femoral neck and radius were predictive of fractures in 49 men with the incident peripheral fractures, whereas their O.R. did not attain the level of statistical significance in 25 men with the incident vertebral fractures. Men, who had both low aBMD and low CSMI ( both T scores < -1), had the fracture risk 3.8 to 4.2 higher than the reference group (both T scores >or= -1). Men, who had both low aBMD and low section modulus (both T scores < -1), had the fracture risk 2.1 to 4.1 higher than the reference group (both T scores >or= -1). In conclusion, men who sustained a fragility fracture during a 90-month follow-up had, at baseline, lower BMC because they had narrower bones but not necessarily less dense. In elderly men, small bone width, low BMC and poor resistance to bending may increase bone fragility. Low bone width seems to be associated with an increased fracture risk in elderly men regardless of aBMD.

Please choose payment method:






(PDF emailed within 0-6 h: $19.90)

Accession: 049497334

Download citation: RISBibTeXText

Related references

Low width of tubular bones is associated with increased risk of fragility fracture in elderly men - the MINOS study. Bone (New York) 38(4): 595-602, 2006

Increased risk of falls and increased bone resorption in elderly men with partial androgen deficiency: the MINOS study. Journal of Clinical Endocrinology and Metabolism 88(11): 5240-5247, 2003

Increased risk of falls, increased bone resorption and decreased bone mineral density in elderly men with hypogonadism The MINOS Study. Journal of Bone and Mineral Research 17(Suppl 1): S174, 2002

Long term prognosis of Scheuermann's disease: The association with fragility fracture - The MINOS cohort. Bone 117: 116-122, 2018

Risk factors of refracture after a fragility fracture in elderly. Archives of Osteoporosis 17(1): 98, 2022

Proteinuria Is Associated With Increased Risk of Fragility Fracture in Men With or at Risk of HIV Infection. Journal of Acquired Immune Deficiency Syndromes 81(3): E85-E91, 2019

High bone turnover is associated with accelerated bone loss but not with increased fracture risk in men aged 50 and over: the prospective MINOS study. Annals of the Rheumatic Diseases 67(9): 1249-1255, 2008

Risk factors for fragility fracture in Seremban district, Malaysia: a comparison of patients with fragility fracture in the orthopedic ward versus those in the outpatient department. Asia-Pacific Journal of Public Health 20(3): 251-257, 2008

Fragility Fracture Risk in Elderly Patients With Cervical Myelopathy. Spine 44(2): 96-102, 2019

Low CD4 Count Is Associated With an Increased Risk of Fragility Fracture in HIV-Infected Patients. Journal of Acquired Immune Deficiency Syndromes (1999) 57(3): 205-210, 2011

Low CD4 count is associated with an increased risk of fragility fracture in HIV-infected patients. Journal of Acquired Immune Deficiency Syndromes 57(3): 205-210, 2011

Bone width is correlated positively with the upper to the lower segment ratio in elderly men- The MINOS study. Bone (New York) 40(1): 194-199, 2007

Bone width is correlated positively with the upper to the lower segment ratio in elderly men--the MINOS study. Bone 40(1): 194-199, 2007

Diabetes and Risk of Post-Fragility Hip Fracture Outcomes in Elderly Patients. International Journal of Endocrinology 2020: 8146196, 2020

Red Cell Distribution Width Is a Risk Factor for Hip Fracture in Elderly Men Without Anemia. Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research 35(5): 869-874, 2020