+ Site Statistics
+ Search Articles
+ Subscribe to Site Feeds
EurekaMag Most Shared ContentMost Shared
EurekaMag PDF Full Text ContentPDF Full Text
+ PDF Full Text
Request PDF Full TextRequest PDF Full Text
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter
Follow on LinkedInFollow on LinkedIn

+ Translate

Magnetic resonance imaging detects early changes in microvascular permeability in xenograft tumors after treatment with the matrix metalloprotease inhibitor Prinomastat

Magnetic resonance imaging detects early changes in microvascular permeability in xenograft tumors after treatment with the matrix metalloprotease inhibitor Prinomastat

Technology in Cancer Research & Treatment 3(4): 377-382

Macromolecular contrast medium-enhanced magnetic resonance imaging was applied to monitor the effect of matrix metalloprotease (MMP) inhibition on microvascular characteristics of human breast cancers implanted in athymic rats. Twice-daily intraperitoneal administration of Prinomastat over 1.5 days induced significant declines in MRI-assayed microvascular permeabilities (p<0.05); but this leak suppression effect had extinguished by the 10(th) day of MMP treatment using the same dose and time schedule. Results demonstrate that Prinomastat produces a rapid but transient decrease in tumor vascular permeability. Contrast-enhanced MRI using macromolecular contrast medium may prove useful as a biomarker for the dynamic MMP biological effect in cancers.

(PDF emailed within 0-6 h: $19.90)

Accession: 049512320

Download citation: RISBibTeXText

PMID: 15270589

DOI: 10.1177/153303460400300408

Related references

Efficacy of Prinomastat) (AG3340), a matrix metalloprotease inhibitor, in treatment of retinal neovascularization. Current Eye Research 24(1): 33-38, 2002

Phase I and pharmacokinetic study of prinomastat, a matrix metalloprotease inhibitor. Clinical Cancer Research 10(3): 909-915, 2004

Prinomastat A potent and selective matrix metalloprotease inhibitor Preclinical and clinical development for oncology. Clendeninn, Neil J , Appelt, Krzysztof Cancer Drug Discovery and Development Matrix metalloproteinase inhibitors in cancer therapy 143-173, 2001

Phase II, parallel-design study of preoperative combined modality therapy and the matrix metalloprotease (mmp) inhibitor prinomastat in patients with esophageal adenocarcinoma. Investigational New Drugs 24(2): 135-140, 2006

Characterization of tumor microvascular structure and permeability: comparison between magnetic resonance imaging and intravital confocal imaging. Journal of Biomedical Optics 15(3): 036004-036004, 2010

A novel contrast medium detects increased permeability of rat injured carotid arteries in magnetic resonance T2 mapping imaging. Journal of Atherosclerosis and Thrombosis 14(2): 65-71, 2007

Increased stromal expression of murine urokinase plasminogen activator in a human breast cancer xenograft model following treatment with the matrix metalloprotease inhibitor, batimastat. Breast Cancer Research & Treatment 68(3): 225-237, August, 2001

Early changes measured by magnetic resonance imaging in cerebral blood flow, blood volume, and blood-brain barrier permeability following dexamethasone treatment in patients with brain tumors. Journal of Neurosurgery 90(2): 300-305, 1999

Spatial mapping of microvascular permeability and tissue blood volume using magnetic resonance imaging. Academic Radiology 3 Suppl 2: S344-S346, 1996

Diffusion-weighted magnetic resonance imaging detects early neuropathology following four vessel occlusion ischemia in the rat. Journal of Magnetic Resonance Imaging 14(3): 207-214, 2001

Magnetic resonance imaging detects suppression of tumor vascular permeability after administration of antibody to vascular endothelial growth factor. Cancer Investigation 16(4): 225-230, 1998

Magnetic resonance imaging surveillance detects early-stage pancreatic cancer in carriers of a p16-Leiden mutation. Gastroenterology 140(3): 850-856, 2011

Microvascular permeability of brain astrocytoma with contrast-enhanced magnetic resonance imaging: correlation analysis with histopathologic grade. Chinese Medical Journal 126(10): 1953-1956, 2013

Increased microvascular permeability in diet-induced hypercholesterolemic rabbits A magnetic resonance imaging-based longitudinal Study. European Heart Journal 24(Abstract Supplement): 306, August-September, 2003

Early beneficial effect of matrix metalloproteinase inhibition on blood-brain barrier permeability as measured by magnetic resonance imaging countered by impaired long-term recovery after stroke in rat brain. Journal of Cerebral Blood Flow and Metabolism 28(2): 431-438, 2007